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A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations

Abstinence rates among smokers attempting to quit remain low despite the wide availability and accessibility of pharmacological smoking cessation treatments. In addition, the prevalence of cessation attempts and abstinence differs by individual-level social factors such as race and ethnicity. Clinic...

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Autores principales: Prom-Wormley, Elizabeth C., Wells, Jonathan L., Landes, Lori, Edmondson, Amy N., Sankoh, Mariam, Jamieson, Brendan, Delk, Kayla J., Surya, Sanya, Bhati, Shambhavi, Clifford, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285878/
https://www.ncbi.nlm.nih.gov/pubmed/37359362
http://dx.doi.org/10.3389/fgene.2023.1103966
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author Prom-Wormley, Elizabeth C.
Wells, Jonathan L.
Landes, Lori
Edmondson, Amy N.
Sankoh, Mariam
Jamieson, Brendan
Delk, Kayla J.
Surya, Sanya
Bhati, Shambhavi
Clifford, James
author_facet Prom-Wormley, Elizabeth C.
Wells, Jonathan L.
Landes, Lori
Edmondson, Amy N.
Sankoh, Mariam
Jamieson, Brendan
Delk, Kayla J.
Surya, Sanya
Bhati, Shambhavi
Clifford, James
author_sort Prom-Wormley, Elizabeth C.
collection PubMed
description Abstinence rates among smokers attempting to quit remain low despite the wide availability and accessibility of pharmacological smoking cessation treatments. In addition, the prevalence of cessation attempts and abstinence differs by individual-level social factors such as race and ethnicity. Clinical treatment of nicotine dependence also continues to be challenged by individual-level variability in effectiveness to promote abstinence. The use of tailored smoking cessation strategies that incorporate information on individual-level social and genetic factors hold promise, although additional pharmacogenomic knowledge is still needed. In particular, genetic variants associated with pharmacological responses to smoking cessation treatment have generally been conducted in populations with participants that self-identify as White race or who are determined to be of European genetic ancestry. These results may not adequately capture the variability across all smokers as a result of understudied differences in allele frequencies across genetic ancestry populations. This suggests that much of the current pharmacogenetic study results for smoking cessation may not apply to all populations. Therefore, clinical application of pharmacogenetic results may exacerbate health inequities by racial and ethnic groups. This scoping review examines the extent to which racial, ethnic, and ancestral groups that experience differences in smoking rates and smoking cessation are represented in the existing body of published pharmacogenetic studies of smoking cessation. We will summarize results by race, ethnicity, and ancestry across pharmacological treatments and study designs. We will also explore current opportunities and challenges in conducting pharmacogenomic research on smoking cessation that encourages greater participant diversity, including practical barriers to clinical utilization of pharmacological smoking cessation treatment and clinical implementation of pharmacogenetic knowledge.
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spelling pubmed-102858782023-06-23 A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations Prom-Wormley, Elizabeth C. Wells, Jonathan L. Landes, Lori Edmondson, Amy N. Sankoh, Mariam Jamieson, Brendan Delk, Kayla J. Surya, Sanya Bhati, Shambhavi Clifford, James Front Genet Genetics Abstinence rates among smokers attempting to quit remain low despite the wide availability and accessibility of pharmacological smoking cessation treatments. In addition, the prevalence of cessation attempts and abstinence differs by individual-level social factors such as race and ethnicity. Clinical treatment of nicotine dependence also continues to be challenged by individual-level variability in effectiveness to promote abstinence. The use of tailored smoking cessation strategies that incorporate information on individual-level social and genetic factors hold promise, although additional pharmacogenomic knowledge is still needed. In particular, genetic variants associated with pharmacological responses to smoking cessation treatment have generally been conducted in populations with participants that self-identify as White race or who are determined to be of European genetic ancestry. These results may not adequately capture the variability across all smokers as a result of understudied differences in allele frequencies across genetic ancestry populations. This suggests that much of the current pharmacogenetic study results for smoking cessation may not apply to all populations. Therefore, clinical application of pharmacogenetic results may exacerbate health inequities by racial and ethnic groups. This scoping review examines the extent to which racial, ethnic, and ancestral groups that experience differences in smoking rates and smoking cessation are represented in the existing body of published pharmacogenetic studies of smoking cessation. We will summarize results by race, ethnicity, and ancestry across pharmacological treatments and study designs. We will also explore current opportunities and challenges in conducting pharmacogenomic research on smoking cessation that encourages greater participant diversity, including practical barriers to clinical utilization of pharmacological smoking cessation treatment and clinical implementation of pharmacogenetic knowledge. Frontiers Media S.A. 2023-06-08 /pmc/articles/PMC10285878/ /pubmed/37359362 http://dx.doi.org/10.3389/fgene.2023.1103966 Text en Copyright © 2023 Prom-Wormley, Wells, Landes, Edmondson, Sankoh, Jamieson, Delk, Surya, Bhati and Clifford. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Prom-Wormley, Elizabeth C.
Wells, Jonathan L.
Landes, Lori
Edmondson, Amy N.
Sankoh, Mariam
Jamieson, Brendan
Delk, Kayla J.
Surya, Sanya
Bhati, Shambhavi
Clifford, James
A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations
title A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations
title_full A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations
title_fullStr A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations
title_full_unstemmed A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations
title_short A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations
title_sort scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285878/
https://www.ncbi.nlm.nih.gov/pubmed/37359362
http://dx.doi.org/10.3389/fgene.2023.1103966
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