Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy

[Image: see text] In this study, we condensed methyl pyropheophorbide-a (2) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin (3a) as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of 3a to generate singlet oxygen, as well as its photody...

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Detalles Bibliográficos
Autores principales: Wu, Huiqiang, Yeo, Sooho, Li, Jiazhu, Wang, Jinjun, Lee, Woo Kyoung, Yoon, Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285954/
https://www.ncbi.nlm.nih.gov/pubmed/37360422
http://dx.doi.org/10.1021/acsomega.3c01807
Descripción
Sumario:[Image: see text] In this study, we condensed methyl pyropheophorbide-a (2) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin (3a) as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of 3a to generate singlet oxygen, as well as its photodynamic effect on A549 and HeLa cells, was investigated. PS exhibited strong phototoxicity and negligible dark toxicity. Its structure was examined by UV–visible spectroscopy, nuclear magnetic resonance, and high-resolution fast atom bombardment mass spectrometry.

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