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Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy
[Image: see text] In this study, we condensed methyl pyropheophorbide-a (2) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin (3a) as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of 3a to generate singlet oxygen, as well as its photody...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285954/ https://www.ncbi.nlm.nih.gov/pubmed/37360422 http://dx.doi.org/10.1021/acsomega.3c01807 |
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author | Wu, Huiqiang Yeo, Sooho Li, Jiazhu Wang, Jinjun Lee, Woo Kyoung Yoon, Il |
author_facet | Wu, Huiqiang Yeo, Sooho Li, Jiazhu Wang, Jinjun Lee, Woo Kyoung Yoon, Il |
author_sort | Wu, Huiqiang |
collection | PubMed |
description | [Image: see text] In this study, we condensed methyl pyropheophorbide-a (2) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin (3a) as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of 3a to generate singlet oxygen, as well as its photodynamic effect on A549 and HeLa cells, was investigated. PS exhibited strong phototoxicity and negligible dark toxicity. Its structure was examined by UV–visible spectroscopy, nuclear magnetic resonance, and high-resolution fast atom bombardment mass spectrometry. |
format | Online Article Text |
id | pubmed-10285954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-102859542023-06-23 Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy Wu, Huiqiang Yeo, Sooho Li, Jiazhu Wang, Jinjun Lee, Woo Kyoung Yoon, Il ACS Omega [Image: see text] In this study, we condensed methyl pyropheophorbide-a (2) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin (3a) as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of 3a to generate singlet oxygen, as well as its photodynamic effect on A549 and HeLa cells, was investigated. PS exhibited strong phototoxicity and negligible dark toxicity. Its structure was examined by UV–visible spectroscopy, nuclear magnetic resonance, and high-resolution fast atom bombardment mass spectrometry. American Chemical Society 2023-06-06 /pmc/articles/PMC10285954/ /pubmed/37360422 http://dx.doi.org/10.1021/acsomega.3c01807 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Wu, Huiqiang Yeo, Sooho Li, Jiazhu Wang, Jinjun Lee, Woo Kyoung Yoon, Il Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy |
title | Long-Wavelength
Absorbing Benzimidazolo-Chlorin for
Enhanced Photodynamic Therapy |
title_full | Long-Wavelength
Absorbing Benzimidazolo-Chlorin for
Enhanced Photodynamic Therapy |
title_fullStr | Long-Wavelength
Absorbing Benzimidazolo-Chlorin for
Enhanced Photodynamic Therapy |
title_full_unstemmed | Long-Wavelength
Absorbing Benzimidazolo-Chlorin for
Enhanced Photodynamic Therapy |
title_short | Long-Wavelength
Absorbing Benzimidazolo-Chlorin for
Enhanced Photodynamic Therapy |
title_sort | long-wavelength
absorbing benzimidazolo-chlorin for
enhanced photodynamic therapy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285954/ https://www.ncbi.nlm.nih.gov/pubmed/37360422 http://dx.doi.org/10.1021/acsomega.3c01807 |
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