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Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy

[Image: see text] In this study, we condensed methyl pyropheophorbide-a (2) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin (3a) as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of 3a to generate singlet oxygen, as well as its photody...

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Autores principales: Wu, Huiqiang, Yeo, Sooho, Li, Jiazhu, Wang, Jinjun, Lee, Woo Kyoung, Yoon, Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285954/
https://www.ncbi.nlm.nih.gov/pubmed/37360422
http://dx.doi.org/10.1021/acsomega.3c01807
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author Wu, Huiqiang
Yeo, Sooho
Li, Jiazhu
Wang, Jinjun
Lee, Woo Kyoung
Yoon, Il
author_facet Wu, Huiqiang
Yeo, Sooho
Li, Jiazhu
Wang, Jinjun
Lee, Woo Kyoung
Yoon, Il
author_sort Wu, Huiqiang
collection PubMed
description [Image: see text] In this study, we condensed methyl pyropheophorbide-a (2) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin (3a) as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of 3a to generate singlet oxygen, as well as its photodynamic effect on A549 and HeLa cells, was investigated. PS exhibited strong phototoxicity and negligible dark toxicity. Its structure was examined by UV–visible spectroscopy, nuclear magnetic resonance, and high-resolution fast atom bombardment mass spectrometry.
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spelling pubmed-102859542023-06-23 Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy Wu, Huiqiang Yeo, Sooho Li, Jiazhu Wang, Jinjun Lee, Woo Kyoung Yoon, Il ACS Omega [Image: see text] In this study, we condensed methyl pyropheophorbide-a (2) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin (3a) as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of 3a to generate singlet oxygen, as well as its photodynamic effect on A549 and HeLa cells, was investigated. PS exhibited strong phototoxicity and negligible dark toxicity. Its structure was examined by UV–visible spectroscopy, nuclear magnetic resonance, and high-resolution fast atom bombardment mass spectrometry. American Chemical Society 2023-06-06 /pmc/articles/PMC10285954/ /pubmed/37360422 http://dx.doi.org/10.1021/acsomega.3c01807 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wu, Huiqiang
Yeo, Sooho
Li, Jiazhu
Wang, Jinjun
Lee, Woo Kyoung
Yoon, Il
Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy
title Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy
title_full Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy
title_fullStr Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy
title_full_unstemmed Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy
title_short Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy
title_sort long-wavelength absorbing benzimidazolo-chlorin for enhanced photodynamic therapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285954/
https://www.ncbi.nlm.nih.gov/pubmed/37360422
http://dx.doi.org/10.1021/acsomega.3c01807
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