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Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program

Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA in addition to depletion of palmitate. We explore whic...

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Detalles Bibliográficos
Autores principales:	Guilherme, Adilson, Rowland, Leslie A., Wetoska, Nicole, Tsagkaraki, Emmanouela, Santos, Kaltinaitis B., Bedard, Alexander H., Henriques, Felipe, Kelly, Mark, Munroe, Sean, Pedersen, David J., Ilkayeva, Olga R., Koves, Timothy R., Tauer, Lauren, Pan, Meixia, Han, Xianlin, Kim, Jason K., Newgard, Christopher B., Muoio, Deborah M., Czech, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286105/ https://www.ncbi.nlm.nih.gov/pubmed/37163372 http://dx.doi.org/10.1016/j.celrep.2023.112488

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