Functionalized Magnetic Nanoparticles for NIR-Induced Photothermal Therapy of Potential Application in Cervical Cancer

[Image: see text] Photothermal therapy (PTT) holds great promise for cancer treatment with its effective ablation of solid tumors. As the essential core point, photothermal agents (PTAs) with excellent photothermal properties and good biocompatibility could help to fulfill highly efficient PTT. Herein, a novel type of nanoplatform Fe(3)O(4)@PDA/ICG (FPI) nanoparticle (NP) was designed and synthesized, which was composed of magnetic Fe(3)O(4) and near-infrared excitable indocyanine green via encapsulation of polydopamine. The FPI NPs showed spherical structures in shape with uniform distribution and good chemical stability. Under 793 nm laser irradiation, FPI NPs could generate hyperthermia of 54.1 °C and photothermal conversion efficiency of 35.21%. The low cytotoxicity of FPI NPs was further evaluated and confirmed on HeLa cells with a high survival rate (90%). Moreover, under laser irradiation (793 nm), FPI NPs showed effective photothermal therapeutic characteristics for HeLa cells. Therefore, FPI NPs, as one of the promising PTAs, have great potential in the field of PTT for tumor treatment.