Antibacterial and Anticancer Activity, Acute Toxicity, and Solubility of Co-crystals of 5-Fluorouracil and Trimethoprim

[Image: see text] 5-Fluorouracil is mainly used for the treatment of tumors and has relatively high toxicity. Trimethoprim is a common broad-spectrum antibiotic agent with extremely poor water solubility. We hoped to solve these problems by synthesizing co-crystals (compound 1) of 5-fluorouracil and...

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Detalles Bibliográficos
Autores principales: Yan, Tianping, Shu, Baoyu, Deng, Xuezhen, Qian, Kun, Pan, Rongbin, Qiu, ShouLiang, Yang, Jie, Fu, Qingxia, Ma, Yuexing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286293/
https://www.ncbi.nlm.nih.gov/pubmed/37360497
http://dx.doi.org/10.1021/acsomega.3c00580

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