Cargando…

Branch Unit Distribution Matters for Gene Delivery

[Image: see text] As a key nonviral gene therapy vector, poly(β-amino ester) (PAE) has demonstrated great potential for clinical application after two decades of development. However, even after extensive efforts in structural optimizations, including screening chemical composition, molecular weight...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yinghao, He, Zhonglei, Wang, Xianqing, Li, Zishan, Johnson, Melissa, Foley, Ruth, Sigen, A., Lyu, Jing, Wang, Wenxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286303/ https://www.ncbi.nlm.nih.gov/pubmed/37220212 http://dx.doi.org/10.1021/acsmacrolett.3c00152

Ejemplares similares

Artificial Intelligence (AI)-Aided Structure Optimization for Enhanced Gene Delivery: The Effect of the Polymer Component Distribution (PCD)
por: Li, Yinghao, et al.
Publicado: (2023)

A New Optimization Strategy of Highly Branched Poly(β-Amino Ester) for Enhanced Gene Delivery: Removal of Small Molecular Weight Components
por: Li, Yinghao, et al.
Publicado: (2023)

3D Macrocyclic Structure Boosted Gene Delivery: Multi-Cyclic Poly(β-Amino Ester)s from Step Growth Polymerization
por: Li, Yinghao, et al.
Publicado: (2023)

Guanidyl-Rich Poly(β Amino Ester)s for Universal Functional Cytosolic Protein Delivery and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Cas9 Ribonucleoprotein Based Gene Editing
por: Wang, Xianqing, et al.
Publicado: (2023)

Hyperbranched Poly(β-amino ester)s (HPAEs) Structure Optimisation for Enhanced Gene Delivery: Non-Ideal Termination Elimination
por: Li, Yinghao, et al.
Publicado: (2022)

CRISPR-Cas9-based non-viral gene editing therapy for topical treatment of recessive dystrophic epidermolysis bullosa
por: Wang, Xianqing, et al.
Publicado: (2023)

Development of Minicircle Vectors Encoding COL7A1 Gene with Human Promoters for Non-Viral Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa
por: Wang, Xianqing, et al.
Publicado: (2021)

An Injectable Chitosan-Based Self-Healable Hydrogel System as an Antibacterial Wound Dressing
por: Wang, Xiaoyu, et al.
Publicado: (2021)

Controlled Polymerization of Acrylamide via One-Pot and One-Step Aqueous Cu(0)-Mediated Reversible-Deactivation Radical Polymerization
por: Li, Zishan, et al.
Publicado: (2023)

Modelling Development in Radical (Co)Polymerization of Multivinyl Monomers
por: Lyu, Jing, et al.
Publicado: (2022)

The transition from linear to highly branched poly(β-amino ester)s: Branching matters for gene delivery
por: Zhou, Dezhong, et al.
Publicado: (2016)

Non-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system
por: O’Keeffe Ahern, Jonathan, et al.
Publicado: (2021)

A Novel Hydrophilic, Antibacterial Chitosan-Based Coating Prepared by Ultrasonic Atomization Assisted LbL Assembly Technique
por: Wang, Xiaoyu, et al.
Publicado: (2023)

Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
por: Liu, Shuai, et al.
Publicado: (2019)

Mode of Delivery in Premature Neonates: Does It Matter?
por: Racusin, Diana A., et al.
Publicado: (2016)

N-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental Bikunin
por: Lai, Ying-Jung J., et al.
Publicado: (2015)

Application of the Spline Interpolation in Simulating the Distribution of Phytoplankton in a Marine NPZD Type Ecosystem Model
por: Li, Xiaona, et al.
Publicado: (2019)

Left bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing
por: Li, Xiaofei, et al.
Publicado: (2020)

Miktoarm Star Polymers: Branched Architectures in Drug Delivery
por: Lotocki, Victor, et al.
Publicado: (2020)

Efficacy evaluation of chimeric antigen receptor-modified human peritoneal macrophages in the treatment of gastric cancer
por: Dong, Xuhui, et al.
Publicado: (2023)

Sweeps in time: leveraging the joint distribution of branch lengths
por: Bisschop, Gertjan, et al.
Publicado: (2021)

White matter changes in Parkinson’s disease
por: Yang, Kai, et al.
Publicado: (2023)

Effects of Wax Molecular Weight Distribution and Branching on Moisture Sensitivity of Asphalt Binders
por: Wang, Wenqi, et al.
Publicado: (2022)

Crosstalk between IL‐15Rα(+) tumor‐associated macrophages and breast cancer cells reduces CD8(+) T cell recruitment
por: Zhang, Wenlong, et al.
Publicado: (2022)

Advances in the Asymmetric Total Synthesis of Natural Products Using Chiral Secondary Amine Catalyzed Reactions of α,β-Unsaturated Aldehydes
por: Wang, Zhonglei
Publicado: (2019)

Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases
por: López-Cano, José Javier, et al.
Publicado: (2021)

High origin of dorsal branch of the ulnar nerve and variations in its branching pattern and distribution: a case report
por: Lama, Polly, et al.
Publicado: (2009)

Azimuthal di-jet correlations with parton branching TMD distributions
por: Bermudez Martinez, A., et al.
Publicado: (2022)

Trigeminal Pain and Its Distribution in Different Trigeminal Nerve Branches
por: Piagkou, Maria Nikolaos, et al.
Publicado: (2012)

Distribution of Matter in the Universe Conference
Publicado: (1991)

To branch or not to branch
por: Leslie, Mitch
Publicado: (2001)

An Update on Isolation Methods for Proteomic Studies of Extracellular Vesicles in Biofluids
por: Li, Jing, et al.
Publicado: (2019)

A Brief Review of OPT101 Sensor Application in Near-Infrared Spectroscopy Instrumentation for Intensive Care Unit Clinics
por: Li, Ting, et al.
Publicado: (2017)

United Formula for the Friction Factor in the Turbulent Region of Pipe Flow
por: Li, Shuolin, et al.
Publicado: (2016)

Capture of dark matter particles by a galaxy in the case of a bimodal distribution of their velocities
por: Parnovsky, Serge, et al.
Publicado: (2022)

The Characterization of Modified Starch Branching Enzymes: Toward the Control of Starch Chain-Length Distributions
por: Li, Cheng, et al.
Publicado: (2015)

miR-1226-3p Promotes Sorafenib Sensitivity of Hepatocellular Carcinoma via Downregulation of DUSP4 Expression
por: Chen, Xianqing, et al.
Publicado: (2019)

Greater periventricular white matter hyperintensity severity in basilar artery branch atheromatous disease
por: Lin, Po-Chen, et al.
Publicado: (2017)

In situ Forming Hyperbranched PEG—Thiolated Hyaluronic Acid Hydrogels With Honey-Mimetic Antibacterial Properties
por: Vasquez, Jeddah Marie, et al.
Publicado: (2021)

Distributions of soil branched glycerol dialkyl glycerol tetraethers from different climate regions of China
por: Wang, M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_fau4165pnpsuu2jhg3fj2vs4ip