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Sequential Unfolding Mechanisms of Monomeric Caspases

[Image: see text] Caspases are evolutionarily conserved cysteinyl proteases that are integral in cell development and apoptosis. All apoptotic caspases evolved from a common ancestor into two distinct subfamilies with either monomeric (initiators) or dimeric (effectors) oligomeric states. The regula...

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Detalles Bibliográficos
Autores principales: Joglekar, Isha, Clark, A. Clay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286309/
https://www.ncbi.nlm.nih.gov/pubmed/37337671
http://dx.doi.org/10.1021/acs.biochem.3c00004