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Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
BACKGROUND: The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN is rarely reported. The combination of anti-GBM disease and MN has been well...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286333/ https://www.ncbi.nlm.nih.gov/pubmed/37349681 http://dx.doi.org/10.1186/s12882-023-03132-2 |
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author | Cheng, Yan-jiao Jia, Xiao-yu Cao, Hong-ru Zhao, Xiao-yi Zhou, Xu-jie Yu, Xiao-juan Xu, Rong Zhou, Fu-de Wang, Su-xia Cui, Zhao Zhao, Ming-hui |
author_facet | Cheng, Yan-jiao Jia, Xiao-yu Cao, Hong-ru Zhao, Xiao-yi Zhou, Xu-jie Yu, Xiao-juan Xu, Rong Zhou, Fu-de Wang, Su-xia Cui, Zhao Zhao, Ming-hui |
author_sort | Cheng, Yan-jiao |
collection | PubMed |
description | BACKGROUND: The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN is rarely reported. The combination of anti-GBM disease and MN has been well documented, though the mechanism behind it remains unclear. CASE PRESENTATION: We describe two siblings diagnosed with pathology-confirmed PLA2R-related MN 1 year apart. And one of the two siblings developed an anti-GBM disease. The high-resolution HLA typing showed identical alleles in both siblings, specifically heterozygotes of DRB1*15:01/*03:01. CONCLUSION: We describe a familial case of PLA2R-related MN supporting the role of genetic factors that HLA-DRB1*15:01 and DRB1*03:01 predispose patients in the development of PLA2R-related MN in the Han Chinese population. The combination of MN and anti-GBM disease may also partially be associated with the same susceptible HLA allele DRB1*15:01. |
format | Online Article Text |
id | pubmed-10286333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102863332023-06-23 Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report Cheng, Yan-jiao Jia, Xiao-yu Cao, Hong-ru Zhao, Xiao-yi Zhou, Xu-jie Yu, Xiao-juan Xu, Rong Zhou, Fu-de Wang, Su-xia Cui, Zhao Zhao, Ming-hui BMC Nephrol Case Report BACKGROUND: The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN is rarely reported. The combination of anti-GBM disease and MN has been well documented, though the mechanism behind it remains unclear. CASE PRESENTATION: We describe two siblings diagnosed with pathology-confirmed PLA2R-related MN 1 year apart. And one of the two siblings developed an anti-GBM disease. The high-resolution HLA typing showed identical alleles in both siblings, specifically heterozygotes of DRB1*15:01/*03:01. CONCLUSION: We describe a familial case of PLA2R-related MN supporting the role of genetic factors that HLA-DRB1*15:01 and DRB1*03:01 predispose patients in the development of PLA2R-related MN in the Han Chinese population. The combination of MN and anti-GBM disease may also partially be associated with the same susceptible HLA allele DRB1*15:01. BioMed Central 2023-06-22 /pmc/articles/PMC10286333/ /pubmed/37349681 http://dx.doi.org/10.1186/s12882-023-03132-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Cheng, Yan-jiao Jia, Xiao-yu Cao, Hong-ru Zhao, Xiao-yi Zhou, Xu-jie Yu, Xiao-juan Xu, Rong Zhou, Fu-de Wang, Su-xia Cui, Zhao Zhao, Ming-hui Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
title | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
title_full | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
title_fullStr | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
title_full_unstemmed | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
title_short | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
title_sort | primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286333/ https://www.ncbi.nlm.nih.gov/pubmed/37349681 http://dx.doi.org/10.1186/s12882-023-03132-2 |
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