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Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report

BACKGROUND: The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN is rarely reported. The combination of anti-GBM disease and MN has been well...

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Autores principales: Cheng, Yan-jiao, Jia, Xiao-yu, Cao, Hong-ru, Zhao, Xiao-yi, Zhou, Xu-jie, Yu, Xiao-juan, Xu, Rong, Zhou, Fu-de, Wang, Su-xia, Cui, Zhao, Zhao, Ming-hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286333/
https://www.ncbi.nlm.nih.gov/pubmed/37349681
http://dx.doi.org/10.1186/s12882-023-03132-2
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author Cheng, Yan-jiao
Jia, Xiao-yu
Cao, Hong-ru
Zhao, Xiao-yi
Zhou, Xu-jie
Yu, Xiao-juan
Xu, Rong
Zhou, Fu-de
Wang, Su-xia
Cui, Zhao
Zhao, Ming-hui
author_facet Cheng, Yan-jiao
Jia, Xiao-yu
Cao, Hong-ru
Zhao, Xiao-yi
Zhou, Xu-jie
Yu, Xiao-juan
Xu, Rong
Zhou, Fu-de
Wang, Su-xia
Cui, Zhao
Zhao, Ming-hui
author_sort Cheng, Yan-jiao
collection PubMed
description BACKGROUND: The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN is rarely reported. The combination of anti-GBM disease and MN has been well documented, though the mechanism behind it remains unclear. CASE PRESENTATION: We describe two siblings diagnosed with pathology-confirmed PLA2R-related MN 1 year apart. And one of the two siblings developed an anti-GBM disease. The high-resolution HLA typing showed identical alleles in both siblings, specifically heterozygotes of DRB1*15:01/*03:01. CONCLUSION: We describe a familial case of PLA2R-related MN supporting the role of genetic factors that HLA-DRB1*15:01 and DRB1*03:01 predispose patients in the development of PLA2R-related MN in the Han Chinese population. The combination of MN and anti-GBM disease may also partially be associated with the same susceptible HLA allele DRB1*15:01.
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spelling pubmed-102863332023-06-23 Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report Cheng, Yan-jiao Jia, Xiao-yu Cao, Hong-ru Zhao, Xiao-yi Zhou, Xu-jie Yu, Xiao-juan Xu, Rong Zhou, Fu-de Wang, Su-xia Cui, Zhao Zhao, Ming-hui BMC Nephrol Case Report BACKGROUND: The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN is rarely reported. The combination of anti-GBM disease and MN has been well documented, though the mechanism behind it remains unclear. CASE PRESENTATION: We describe two siblings diagnosed with pathology-confirmed PLA2R-related MN 1 year apart. And one of the two siblings developed an anti-GBM disease. The high-resolution HLA typing showed identical alleles in both siblings, specifically heterozygotes of DRB1*15:01/*03:01. CONCLUSION: We describe a familial case of PLA2R-related MN supporting the role of genetic factors that HLA-DRB1*15:01 and DRB1*03:01 predispose patients in the development of PLA2R-related MN in the Han Chinese population. The combination of MN and anti-GBM disease may also partially be associated with the same susceptible HLA allele DRB1*15:01. BioMed Central 2023-06-22 /pmc/articles/PMC10286333/ /pubmed/37349681 http://dx.doi.org/10.1186/s12882-023-03132-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Cheng, Yan-jiao
Jia, Xiao-yu
Cao, Hong-ru
Zhao, Xiao-yi
Zhou, Xu-jie
Yu, Xiao-juan
Xu, Rong
Zhou, Fu-de
Wang, Su-xia
Cui, Zhao
Zhao, Ming-hui
Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
title Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
title_full Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
title_fullStr Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
title_full_unstemmed Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
title_short Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
title_sort primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286333/
https://www.ncbi.nlm.nih.gov/pubmed/37349681
http://dx.doi.org/10.1186/s12882-023-03132-2
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