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Serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the Ribeirão Preto and São Luiz cohorts

OBJECTIVE: To evaluate the association between second trimester plasma cytokine levels in asymptomatic pregnant women and preterm births (PTB) in an attempt to identify a possible predictor of preterm birth. METHODS: The study design was a nested case–control study including women with singleton a g...

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Autores principales: Turra, Suzana Eggers, Damaso, Ênio Luis, Veiga, Eduardo Carvalho de Arruda, Cardoso, Viviane Cunha, Bettiol, Heloisa, Cavalli, Ricardo Carvalho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286364/
https://www.ncbi.nlm.nih.gov/pubmed/37344822
http://dx.doi.org/10.1186/s12884-023-05791-3
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author Turra, Suzana Eggers
Damaso, Ênio Luis
Veiga, Eduardo Carvalho de Arruda
Cardoso, Viviane Cunha
Bettiol, Heloisa
Cavalli, Ricardo Carvalho
author_facet Turra, Suzana Eggers
Damaso, Ênio Luis
Veiga, Eduardo Carvalho de Arruda
Cardoso, Viviane Cunha
Bettiol, Heloisa
Cavalli, Ricardo Carvalho
author_sort Turra, Suzana Eggers
collection PubMed
description OBJECTIVE: To evaluate the association between second trimester plasma cytokine levels in asymptomatic pregnant women and preterm births (PTB) in an attempt to identify a possible predictor of preterm birth. METHODS: The study design was a nested case–control study including women with singleton a gestational age between 20–25(+ 6) weeks from two Brazilian cities. The patients were interviewed, Venous blood samples were collected. The participants were again evaluated at birth. A total of 197 women with PTB comprised the case group. The control group was selected among term births (426 patients). Forty-one cytokines were compared between groups. RESULTS: When only spontaneous PTB were analyzed, GRO, sCD40L and MCP-1 levels were lower in the case group (p < 0.05). Logarithmic transformation was performed for cytokines with discrepant results, which showed increased levels of IL-2 in the group of spontaneous PTB (p < 0.05). In both analyses, the incidence of maternal smoking and of a history of preterm delivery differed significantly between the case and control groups. In multivariate analysis, only serum GRO levels differed between the case and control groups. CONCLUSION: Lower second trimester serum levels of GRO in asymptomatic women are associated with a larger number of PTB. This finding may reflect a deficient maternal inflammatory response.
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spelling pubmed-102863642023-06-23 Serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the Ribeirão Preto and São Luiz cohorts Turra, Suzana Eggers Damaso, Ênio Luis Veiga, Eduardo Carvalho de Arruda Cardoso, Viviane Cunha Bettiol, Heloisa Cavalli, Ricardo Carvalho BMC Pregnancy Childbirth Research OBJECTIVE: To evaluate the association between second trimester plasma cytokine levels in asymptomatic pregnant women and preterm births (PTB) in an attempt to identify a possible predictor of preterm birth. METHODS: The study design was a nested case–control study including women with singleton a gestational age between 20–25(+ 6) weeks from two Brazilian cities. The patients were interviewed, Venous blood samples were collected. The participants were again evaluated at birth. A total of 197 women with PTB comprised the case group. The control group was selected among term births (426 patients). Forty-one cytokines were compared between groups. RESULTS: When only spontaneous PTB were analyzed, GRO, sCD40L and MCP-1 levels were lower in the case group (p < 0.05). Logarithmic transformation was performed for cytokines with discrepant results, which showed increased levels of IL-2 in the group of spontaneous PTB (p < 0.05). In both analyses, the incidence of maternal smoking and of a history of preterm delivery differed significantly between the case and control groups. In multivariate analysis, only serum GRO levels differed between the case and control groups. CONCLUSION: Lower second trimester serum levels of GRO in asymptomatic women are associated with a larger number of PTB. This finding may reflect a deficient maternal inflammatory response. BioMed Central 2023-06-21 /pmc/articles/PMC10286364/ /pubmed/37344822 http://dx.doi.org/10.1186/s12884-023-05791-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Turra, Suzana Eggers
Damaso, Ênio Luis
Veiga, Eduardo Carvalho de Arruda
Cardoso, Viviane Cunha
Bettiol, Heloisa
Cavalli, Ricardo Carvalho
Serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the Ribeirão Preto and São Luiz cohorts
title Serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the Ribeirão Preto and São Luiz cohorts
title_full Serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the Ribeirão Preto and São Luiz cohorts
title_fullStr Serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the Ribeirão Preto and São Luiz cohorts
title_full_unstemmed Serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the Ribeirão Preto and São Luiz cohorts
title_short Serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the Ribeirão Preto and São Luiz cohorts
title_sort serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the ribeirão preto and são luiz cohorts
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286364/
https://www.ncbi.nlm.nih.gov/pubmed/37344822
http://dx.doi.org/10.1186/s12884-023-05791-3
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