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Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is characterized by a progressive degeneration of dopaminergic neurons, which leads to irreversible loss of peripheral motor functions. Death of dopaminergic neurons induces an inflammatory response in microglial cells, which further exacerbates neuronal loss. Re...

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Detalles Bibliográficos
Autores principales:	Amo-Aparicio, Jesus, Daly, Jonathan, Højen, Jesper Falkesgaard, Dinarello, Charles A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286423/ https://www.ncbi.nlm.nih.gov/pubmed/37349821 http://dx.doi.org/10.1186/s12974-023-02830-w

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