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Risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project

BACKGROUND: Knowledge about the risks of drugs during pregnancy is continuously evolving due to the frequent publication of a large number of epidemiological studies. Systematic reviews and meta-analyses therefore need to be regularly updated to reflect these advances. To improve dissemination of th...

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Autores principales: Picot, Cyndie, Ajiji, Priscilla, Jurek, Lucie, Nourredine, Mikail, Massardier, Jérôme, Peron, Audrey, Cucherat, Michel, Cottin, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286473/
https://www.ncbi.nlm.nih.gov/pubmed/37344917
http://dx.doi.org/10.1186/s13643-023-02256-8
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author Picot, Cyndie
Ajiji, Priscilla
Jurek, Lucie
Nourredine, Mikail
Massardier, Jérôme
Peron, Audrey
Cucherat, Michel
Cottin, Judith
author_facet Picot, Cyndie
Ajiji, Priscilla
Jurek, Lucie
Nourredine, Mikail
Massardier, Jérôme
Peron, Audrey
Cucherat, Michel
Cottin, Judith
author_sort Picot, Cyndie
collection PubMed
description BACKGROUND: Knowledge about the risks of drugs during pregnancy is continuously evolving due to the frequent publication of a large number of epidemiological studies. Systematic reviews and meta-analyses therefore need to be regularly updated to reflect these advances. To improve dissemination of this updated information, we developed an initiative of real-time full-scale living meta-analyses relying on an open online dissemination platform (www.metapreg.org). METHOD: All living meta-analyses performed in this project will be conducted in accordance with this master protocol after adaptation of the search strategy. A systematic literature search of PubMed and Embase will be performed. All analytical studies (e.g., cohort, case-control, randomized studies) reporting original empirical findings on the association between in utero exposure to drugs and adverse pregnancy outcomes will be included. Study screening and data extraction will be performed in a semi-automation way supervised by a biocurator. A risk of bias will be assessed using the ROBINS-I tools. All clinically relevant pregnancy adverse outcomes (malformations, stillbirths, neuro-developmental disorders, pre-eclampsia, etc.) available in the included studies will be pooled through random-effects meta-analysis. Heterogeneity will be evaluated by I(2) statistics. DISCUSSION: Our living systematic reviews and subsequent updates will inform the medical, regulatory, and health policy communities as the news results evolve to guide decisions on the proper use of drugs during the pregnancy. SYSTEMATIC REVIEW REGISTRATION: Open Science Framework (OSF) registries SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-023-02256-8.
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spelling pubmed-102864732023-06-23 Risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project Picot, Cyndie Ajiji, Priscilla Jurek, Lucie Nourredine, Mikail Massardier, Jérôme Peron, Audrey Cucherat, Michel Cottin, Judith Syst Rev Protocol BACKGROUND: Knowledge about the risks of drugs during pregnancy is continuously evolving due to the frequent publication of a large number of epidemiological studies. Systematic reviews and meta-analyses therefore need to be regularly updated to reflect these advances. To improve dissemination of this updated information, we developed an initiative of real-time full-scale living meta-analyses relying on an open online dissemination platform (www.metapreg.org). METHOD: All living meta-analyses performed in this project will be conducted in accordance with this master protocol after adaptation of the search strategy. A systematic literature search of PubMed and Embase will be performed. All analytical studies (e.g., cohort, case-control, randomized studies) reporting original empirical findings on the association between in utero exposure to drugs and adverse pregnancy outcomes will be included. Study screening and data extraction will be performed in a semi-automation way supervised by a biocurator. A risk of bias will be assessed using the ROBINS-I tools. All clinically relevant pregnancy adverse outcomes (malformations, stillbirths, neuro-developmental disorders, pre-eclampsia, etc.) available in the included studies will be pooled through random-effects meta-analysis. Heterogeneity will be evaluated by I(2) statistics. DISCUSSION: Our living systematic reviews and subsequent updates will inform the medical, regulatory, and health policy communities as the news results evolve to guide decisions on the proper use of drugs during the pregnancy. SYSTEMATIC REVIEW REGISTRATION: Open Science Framework (OSF) registries SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-023-02256-8. BioMed Central 2023-06-21 /pmc/articles/PMC10286473/ /pubmed/37344917 http://dx.doi.org/10.1186/s13643-023-02256-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Protocol
Picot, Cyndie
Ajiji, Priscilla
Jurek, Lucie
Nourredine, Mikail
Massardier, Jérôme
Peron, Audrey
Cucherat, Michel
Cottin, Judith
Risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project
title Risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project
title_full Risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project
title_fullStr Risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project
title_full_unstemmed Risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project
title_short Risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project
title_sort risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metapreg project
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286473/
https://www.ncbi.nlm.nih.gov/pubmed/37344917
http://dx.doi.org/10.1186/s13643-023-02256-8
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