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Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders
Abnormal mitochondrial morphology and metabolic dysfunction have been observed in many neurodegenerative disorders (NDDs). Mitochondrial dysfunction can be caused by aberrant mitochondrial DNA, mutant nuclear proteins that interact with mitochondria directly or indirectly, or for unknown reasons. Si...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286591/ https://www.ncbi.nlm.nih.gov/pubmed/36043795 http://dx.doi.org/10.2174/1570159X20666220830112408 |
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author | Almikhlafi, Mohannad A. Karami, Mohammed M. Jana, Ankit Alqurashi, Thamer M. Majrashi, Mohammed Alghamdi, Badrah S. Ashraf, Ghulam Md. |
author_facet | Almikhlafi, Mohannad A. Karami, Mohammed M. Jana, Ankit Alqurashi, Thamer M. Majrashi, Mohammed Alghamdi, Badrah S. Ashraf, Ghulam Md. |
author_sort | Almikhlafi, Mohannad A. |
collection | PubMed |
description | Abnormal mitochondrial morphology and metabolic dysfunction have been observed in many neurodegenerative disorders (NDDs). Mitochondrial dysfunction can be caused by aberrant mitochondrial DNA, mutant nuclear proteins that interact with mitochondria directly or indirectly, or for unknown reasons. Since mitochondria play a significant role in neurodegeneration, mitochondria-targeted therapies represent a prosperous direction for the development of novel drug compounds that can be used to treat NDDs. This review gives a brief description of how mitochondrial abnormalities lead to various NDDs such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. We further explore the promising therapeutic effectiveness of mitochondria-directed antioxidants, MitoQ, MitoVitE, MitoPBN, and dimebon. We have also discussed the possibility of mitochondrial gene therapy as a therapeutic option for these NDDs. |
format | Online Article Text |
id | pubmed-10286591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-102865912023-10-12 Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders Almikhlafi, Mohannad A. Karami, Mohammed M. Jana, Ankit Alqurashi, Thamer M. Majrashi, Mohammed Alghamdi, Badrah S. Ashraf, Ghulam Md. Curr Neuropharmacol Neurology Abnormal mitochondrial morphology and metabolic dysfunction have been observed in many neurodegenerative disorders (NDDs). Mitochondrial dysfunction can be caused by aberrant mitochondrial DNA, mutant nuclear proteins that interact with mitochondria directly or indirectly, or for unknown reasons. Since mitochondria play a significant role in neurodegeneration, mitochondria-targeted therapies represent a prosperous direction for the development of novel drug compounds that can be used to treat NDDs. This review gives a brief description of how mitochondrial abnormalities lead to various NDDs such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. We further explore the promising therapeutic effectiveness of mitochondria-directed antioxidants, MitoQ, MitoVitE, MitoPBN, and dimebon. We have also discussed the possibility of mitochondrial gene therapy as a therapeutic option for these NDDs. Bentham Science Publishers 2023-04-12 2023-04-12 /pmc/articles/PMC10286591/ /pubmed/36043795 http://dx.doi.org/10.2174/1570159X20666220830112408 Text en © 2023 Bentham Science Publishers https://creativecommons.org/licenses/by/4.0/© 2023 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode) |
spellingShingle | Neurology Almikhlafi, Mohannad A. Karami, Mohammed M. Jana, Ankit Alqurashi, Thamer M. Majrashi, Mohammed Alghamdi, Badrah S. Ashraf, Ghulam Md. Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders |
title | Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders |
title_full | Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders |
title_fullStr | Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders |
title_full_unstemmed | Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders |
title_short | Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders |
title_sort | mitochondrial medicine: a promising therapeutic option against various neurodegenerative disorders |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286591/ https://www.ncbi.nlm.nih.gov/pubmed/36043795 http://dx.doi.org/10.2174/1570159X20666220830112408 |
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