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Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders

Abnormal mitochondrial morphology and metabolic dysfunction have been observed in many neurodegenerative disorders (NDDs). Mitochondrial dysfunction can be caused by aberrant mitochondrial DNA, mutant nuclear proteins that interact with mitochondria directly or indirectly, or for unknown reasons. Si...

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Autores principales: Almikhlafi, Mohannad A., Karami, Mohammed M., Jana, Ankit, Alqurashi, Thamer M., Majrashi, Mohammed, Alghamdi, Badrah S., Ashraf, Ghulam Md.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286591/
https://www.ncbi.nlm.nih.gov/pubmed/36043795
http://dx.doi.org/10.2174/1570159X20666220830112408
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author Almikhlafi, Mohannad A.
Karami, Mohammed M.
Jana, Ankit
Alqurashi, Thamer M.
Majrashi, Mohammed
Alghamdi, Badrah S.
Ashraf, Ghulam Md.
author_facet Almikhlafi, Mohannad A.
Karami, Mohammed M.
Jana, Ankit
Alqurashi, Thamer M.
Majrashi, Mohammed
Alghamdi, Badrah S.
Ashraf, Ghulam Md.
author_sort Almikhlafi, Mohannad A.
collection PubMed
description Abnormal mitochondrial morphology and metabolic dysfunction have been observed in many neurodegenerative disorders (NDDs). Mitochondrial dysfunction can be caused by aberrant mitochondrial DNA, mutant nuclear proteins that interact with mitochondria directly or indirectly, or for unknown reasons. Since mitochondria play a significant role in neurodegeneration, mitochondria-targeted therapies represent a prosperous direction for the development of novel drug compounds that can be used to treat NDDs. This review gives a brief description of how mitochondrial abnormalities lead to various NDDs such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. We further explore the promising therapeutic effectiveness of mitochondria-directed antioxidants, MitoQ, MitoVitE, MitoPBN, and dimebon. We have also discussed the possibility of mitochondrial gene therapy as a therapeutic option for these NDDs.
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spelling pubmed-102865912023-10-12 Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders Almikhlafi, Mohannad A. Karami, Mohammed M. Jana, Ankit Alqurashi, Thamer M. Majrashi, Mohammed Alghamdi, Badrah S. Ashraf, Ghulam Md. Curr Neuropharmacol Neurology Abnormal mitochondrial morphology and metabolic dysfunction have been observed in many neurodegenerative disorders (NDDs). Mitochondrial dysfunction can be caused by aberrant mitochondrial DNA, mutant nuclear proteins that interact with mitochondria directly or indirectly, or for unknown reasons. Since mitochondria play a significant role in neurodegeneration, mitochondria-targeted therapies represent a prosperous direction for the development of novel drug compounds that can be used to treat NDDs. This review gives a brief description of how mitochondrial abnormalities lead to various NDDs such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. We further explore the promising therapeutic effectiveness of mitochondria-directed antioxidants, MitoQ, MitoVitE, MitoPBN, and dimebon. We have also discussed the possibility of mitochondrial gene therapy as a therapeutic option for these NDDs. Bentham Science Publishers 2023-04-12 2023-04-12 /pmc/articles/PMC10286591/ /pubmed/36043795 http://dx.doi.org/10.2174/1570159X20666220830112408 Text en © 2023 Bentham Science Publishers https://creativecommons.org/licenses/by/4.0/© 2023 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode)
spellingShingle Neurology
Almikhlafi, Mohannad A.
Karami, Mohammed M.
Jana, Ankit
Alqurashi, Thamer M.
Majrashi, Mohammed
Alghamdi, Badrah S.
Ashraf, Ghulam Md.
Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders
title Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders
title_full Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders
title_fullStr Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders
title_full_unstemmed Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders
title_short Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders
title_sort mitochondrial medicine: a promising therapeutic option against various neurodegenerative disorders
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286591/
https://www.ncbi.nlm.nih.gov/pubmed/36043795
http://dx.doi.org/10.2174/1570159X20666220830112408
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