Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages

INTRODUCTION: Macrophages are essential cells of the immune system that alter their inflammatory profile depending on their microenvironment. Alternative polyadenylation in the 3’UTR (3’UTR-APA) and intronic polyadenylation (IPA) are mechanisms that modulate gene expression, particularly in cancer a...

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Detalles Bibliográficos
Autores principales: Wilton, Joana, de Mendonça, Filipa Lopes, Pereira-Castro, Isabel, Tellier, Michael, Nojima, Takayuki, Costa, Angela M., Freitas, Jaime, Murphy, Shona, Oliveira, Maria Jose, Proudfoot, Nicholas J., Moreira, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286830/
https://www.ncbi.nlm.nih.gov/pubmed/37359548
http://dx.doi.org/10.3389/fimmu.2023.1182525

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