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How can we deliver on the promise of precision medicine in oncology and beyond? A practical roadmap for action
BACKGROUND: Precision medicine (PM) is a form of personalized medicine that recognizes that individuals with the same condition may have different underlying factors and uses molecular information to provide tailored treatments. This approach can improve treatment outcomes and transform lives throug...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286856/ https://www.ncbi.nlm.nih.gov/pubmed/37359405 http://dx.doi.org/10.1002/hsr2.1349 |
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author | Baird, Anne‐Marie Westphalen, C. Benedikt Blum, Sandra Nafria, Begonya Knott, Tanya Sargeant, Ify Harnik, Helena Brooke, Nicholas Wicki, Nicole Wong‐Rieger, Durhane |
author_facet | Baird, Anne‐Marie Westphalen, C. Benedikt Blum, Sandra Nafria, Begonya Knott, Tanya Sargeant, Ify Harnik, Helena Brooke, Nicholas Wicki, Nicole Wong‐Rieger, Durhane |
author_sort | Baird, Anne‐Marie |
collection | PubMed |
description | BACKGROUND: Precision medicine (PM) is a form of personalized medicine that recognizes that individuals with the same condition may have different underlying factors and uses molecular information to provide tailored treatments. This approach can improve treatment outcomes and transform lives through favorable risk/benefit ratios, avoidance of ineffective interventions, and possible cost savings, as evidenced in the field of lung cancer and other oncology/therapeutic settings, including cardiac disease, diabetes, and rare diseases. However, the potential benefits of PM have yet to be fully realized. DISCUSSION: There are many barriers to the implementation of PM in clinical practice, including fragmentation of the PM landscape, siloed approaches to address shared challenges, unwarranted variation in availability and access to PM, lack of standardization, and limited understanding of patients' experience and needs throughout the PM pathway. We believe that a diverse, intersectoral multistakeholder collaboration, with three main pillars of activity: generation of data to demonstrate the benefit of PM, education to support informed decision‐making, and addressing barriers across the patient pathway, is necessary to reach the shared goal of making PM an accessible and sustainable reality. Besides healthcare providers, researchers, policymakers/regulators/payers, and industry representatives, patients in particular must be equal partners and should be central to the PM approach―from early research through to clinical trials and approval of new treatments―to ensure it represents their entire experience and identifies barriers, solutions, and opportunities at the point of delivery. CONCLUSION: We propose a practical and iterative roadmap to advance PM and call for all stakeholders across the healthcare system to employ a collaborative, cocreated, patient‐centered methodology to close gaps and fully realize the potential of PM. |
format | Online Article Text |
id | pubmed-10286856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102868562023-06-23 How can we deliver on the promise of precision medicine in oncology and beyond? A practical roadmap for action Baird, Anne‐Marie Westphalen, C. Benedikt Blum, Sandra Nafria, Begonya Knott, Tanya Sargeant, Ify Harnik, Helena Brooke, Nicholas Wicki, Nicole Wong‐Rieger, Durhane Health Sci Rep Perspective BACKGROUND: Precision medicine (PM) is a form of personalized medicine that recognizes that individuals with the same condition may have different underlying factors and uses molecular information to provide tailored treatments. This approach can improve treatment outcomes and transform lives through favorable risk/benefit ratios, avoidance of ineffective interventions, and possible cost savings, as evidenced in the field of lung cancer and other oncology/therapeutic settings, including cardiac disease, diabetes, and rare diseases. However, the potential benefits of PM have yet to be fully realized. DISCUSSION: There are many barriers to the implementation of PM in clinical practice, including fragmentation of the PM landscape, siloed approaches to address shared challenges, unwarranted variation in availability and access to PM, lack of standardization, and limited understanding of patients' experience and needs throughout the PM pathway. We believe that a diverse, intersectoral multistakeholder collaboration, with three main pillars of activity: generation of data to demonstrate the benefit of PM, education to support informed decision‐making, and addressing barriers across the patient pathway, is necessary to reach the shared goal of making PM an accessible and sustainable reality. Besides healthcare providers, researchers, policymakers/regulators/payers, and industry representatives, patients in particular must be equal partners and should be central to the PM approach―from early research through to clinical trials and approval of new treatments―to ensure it represents their entire experience and identifies barriers, solutions, and opportunities at the point of delivery. CONCLUSION: We propose a practical and iterative roadmap to advance PM and call for all stakeholders across the healthcare system to employ a collaborative, cocreated, patient‐centered methodology to close gaps and fully realize the potential of PM. John Wiley and Sons Inc. 2023-06-22 /pmc/articles/PMC10286856/ /pubmed/37359405 http://dx.doi.org/10.1002/hsr2.1349 Text en © 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Perspective Baird, Anne‐Marie Westphalen, C. Benedikt Blum, Sandra Nafria, Begonya Knott, Tanya Sargeant, Ify Harnik, Helena Brooke, Nicholas Wicki, Nicole Wong‐Rieger, Durhane How can we deliver on the promise of precision medicine in oncology and beyond? A practical roadmap for action |
title | How can we deliver on the promise of precision medicine in oncology and beyond? A practical roadmap for action |
title_full | How can we deliver on the promise of precision medicine in oncology and beyond? A practical roadmap for action |
title_fullStr | How can we deliver on the promise of precision medicine in oncology and beyond? A practical roadmap for action |
title_full_unstemmed | How can we deliver on the promise of precision medicine in oncology and beyond? A practical roadmap for action |
title_short | How can we deliver on the promise of precision medicine in oncology and beyond? A practical roadmap for action |
title_sort | how can we deliver on the promise of precision medicine in oncology and beyond? a practical roadmap for action |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286856/ https://www.ncbi.nlm.nih.gov/pubmed/37359405 http://dx.doi.org/10.1002/hsr2.1349 |
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