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A systematic review: facial, dental and orthodontic findings and orofacial diagnostics in patients with FASD

BACKGROUND: The fetal alcohol spectrum disorder is a group of developmental disorders caused by maternal alcohol consumption. Patients with fetal alcohol syndrome show abnormal orofacial features. This review presents an overview over the facial, oral, dental or orthodontic findings and diagnostic t...

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Autores principales: Blanck-Lubarsch, Moritz, Dirksen, Dieter, Feldmann, Reinhold, Hohoff, Ariane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287022/
https://www.ncbi.nlm.nih.gov/pubmed/37360373
http://dx.doi.org/10.3389/fped.2023.1169570
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author Blanck-Lubarsch, Moritz
Dirksen, Dieter
Feldmann, Reinhold
Hohoff, Ariane
author_facet Blanck-Lubarsch, Moritz
Dirksen, Dieter
Feldmann, Reinhold
Hohoff, Ariane
author_sort Blanck-Lubarsch, Moritz
collection PubMed
description BACKGROUND: The fetal alcohol spectrum disorder is a group of developmental disorders caused by maternal alcohol consumption. Patients with fetal alcohol syndrome show abnormal orofacial features. This review presents an overview over the facial, oral, dental or orthodontic findings and diagnostic tools concerning these features. METHODS: For this systematic review Cochrane, Medline and Embase databases were considered and the review was performed according to the PRISMA checklist. Two independent reviewers evaluated all studies and recorded results in a summary of findings table. Risk of bias was analyzed via Quadas-2 checklist. RESULTS: 61 studies were eligible for inclusion. All included studies were clinical studies. Methods and results of the studies were not comparable, guidelines or methods for the detection of FASD varied across studies. Facial features most often measured or found as distinguishing parameter were: palpebral fissure length, interpupillary or innercanthal distance, philtrum, upper lip, midfacial hypoplasia or head circumference. CONCLUSIONS: This review shows that to date a multitude of heterogeneous guidelines exists for the diagnosis of FASD. Uniform, objective diagnostic criteria and parameters for the orofacial region in FASD diagnosis are needed. A bio database with values and parameters for different ethnicities and age groups should be made available for diagnosis.
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spelling pubmed-102870222023-06-23 A systematic review: facial, dental and orthodontic findings and orofacial diagnostics in patients with FASD Blanck-Lubarsch, Moritz Dirksen, Dieter Feldmann, Reinhold Hohoff, Ariane Front Pediatr Pediatrics BACKGROUND: The fetal alcohol spectrum disorder is a group of developmental disorders caused by maternal alcohol consumption. Patients with fetal alcohol syndrome show abnormal orofacial features. This review presents an overview over the facial, oral, dental or orthodontic findings and diagnostic tools concerning these features. METHODS: For this systematic review Cochrane, Medline and Embase databases were considered and the review was performed according to the PRISMA checklist. Two independent reviewers evaluated all studies and recorded results in a summary of findings table. Risk of bias was analyzed via Quadas-2 checklist. RESULTS: 61 studies were eligible for inclusion. All included studies were clinical studies. Methods and results of the studies were not comparable, guidelines or methods for the detection of FASD varied across studies. Facial features most often measured or found as distinguishing parameter were: palpebral fissure length, interpupillary or innercanthal distance, philtrum, upper lip, midfacial hypoplasia or head circumference. CONCLUSIONS: This review shows that to date a multitude of heterogeneous guidelines exists for the diagnosis of FASD. Uniform, objective diagnostic criteria and parameters for the orofacial region in FASD diagnosis are needed. A bio database with values and parameters for different ethnicities and age groups should be made available for diagnosis. Frontiers Media S.A. 2023-06-08 /pmc/articles/PMC10287022/ /pubmed/37360373 http://dx.doi.org/10.3389/fped.2023.1169570 Text en © 2023 Blanck-Lubarsch, Dirksen, Feldmann and Hohoff. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Blanck-Lubarsch, Moritz
Dirksen, Dieter
Feldmann, Reinhold
Hohoff, Ariane
A systematic review: facial, dental and orthodontic findings and orofacial diagnostics in patients with FASD
title A systematic review: facial, dental and orthodontic findings and orofacial diagnostics in patients with FASD
title_full A systematic review: facial, dental and orthodontic findings and orofacial diagnostics in patients with FASD
title_fullStr A systematic review: facial, dental and orthodontic findings and orofacial diagnostics in patients with FASD
title_full_unstemmed A systematic review: facial, dental and orthodontic findings and orofacial diagnostics in patients with FASD
title_short A systematic review: facial, dental and orthodontic findings and orofacial diagnostics in patients with FASD
title_sort systematic review: facial, dental and orthodontic findings and orofacial diagnostics in patients with fasd
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287022/
https://www.ncbi.nlm.nih.gov/pubmed/37360373
http://dx.doi.org/10.3389/fped.2023.1169570
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