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Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'
Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287153/ https://www.ncbi.nlm.nih.gov/pubmed/37347515 http://dx.doi.org/10.7554/eLife.85370 |
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author | Li, Yutian Sarma, Anish A Lee, Iris T Tan, Fayth Hui Abrams, Michael J Condiotte, Zevin J Heithe, Martin Raffiee, Misha Dabiri, John O Gold, David A Goentoro, Lea |
author_facet | Li, Yutian Sarma, Anish A Lee, Iris T Tan, Fayth Hui Abrams, Michael J Condiotte, Zevin J Heithe, Martin Raffiee, Misha Dabiri, John O Gold, David A Goentoro, Lea |
author_sort | Li, Yutian |
collection | PubMed |
description | Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in flies (Sustar and Tuthill, 2023). Here we discuss that differences in the amputation method, treatment concentrations, age of the animals, and stress management explain why they did not observe a regenerative response in flies. Typically, 30–50% of treated flies showed response in our assay. |
format | Online Article Text |
id | pubmed-10287153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-102871532023-06-23 Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' Li, Yutian Sarma, Anish A Lee, Iris T Tan, Fayth Hui Abrams, Michael J Condiotte, Zevin J Heithe, Martin Raffiee, Misha Dabiri, John O Gold, David A Goentoro, Lea eLife Evolutionary Biology Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in flies (Sustar and Tuthill, 2023). Here we discuss that differences in the amputation method, treatment concentrations, age of the animals, and stress management explain why they did not observe a regenerative response in flies. Typically, 30–50% of treated flies showed response in our assay. eLife Sciences Publications, Ltd 2023-06-22 /pmc/articles/PMC10287153/ /pubmed/37347515 http://dx.doi.org/10.7554/eLife.85370 Text en © 2023, Li et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Evolutionary Biology Li, Yutian Sarma, Anish A Lee, Iris T Tan, Fayth Hui Abrams, Michael J Condiotte, Zevin J Heithe, Martin Raffiee, Misha Dabiri, John O Gold, David A Goentoro, Lea Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_full | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_fullStr | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_full_unstemmed | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_short | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_sort | response to comment on 'a conserved strategy for inducing appendage regeneration in moon jellyfish, drosophila, and mice' |
topic | Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287153/ https://www.ncbi.nlm.nih.gov/pubmed/37347515 http://dx.doi.org/10.7554/eLife.85370 |
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