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Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'

Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in...

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Autores principales: Li, Yutian, Sarma, Anish A, Lee, Iris T, Tan, Fayth Hui, Abrams, Michael J, Condiotte, Zevin J, Heithe, Martin, Raffiee, Misha, Dabiri, John O, Gold, David A, Goentoro, Lea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287153/
https://www.ncbi.nlm.nih.gov/pubmed/37347515
http://dx.doi.org/10.7554/eLife.85370
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author Li, Yutian
Sarma, Anish A
Lee, Iris T
Tan, Fayth Hui
Abrams, Michael J
Condiotte, Zevin J
Heithe, Martin
Raffiee, Misha
Dabiri, John O
Gold, David A
Goentoro, Lea
author_facet Li, Yutian
Sarma, Anish A
Lee, Iris T
Tan, Fayth Hui
Abrams, Michael J
Condiotte, Zevin J
Heithe, Martin
Raffiee, Misha
Dabiri, John O
Gold, David A
Goentoro, Lea
author_sort Li, Yutian
collection PubMed
description Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in flies (Sustar and Tuthill, 2023). Here we discuss that differences in the amputation method, treatment concentrations, age of the animals, and stress management explain why they did not observe a regenerative response in flies. Typically, 30–50% of treated flies showed response in our assay.
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spelling pubmed-102871532023-06-23 Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' Li, Yutian Sarma, Anish A Lee, Iris T Tan, Fayth Hui Abrams, Michael J Condiotte, Zevin J Heithe, Martin Raffiee, Misha Dabiri, John O Gold, David A Goentoro, Lea eLife Evolutionary Biology Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in flies (Sustar and Tuthill, 2023). Here we discuss that differences in the amputation method, treatment concentrations, age of the animals, and stress management explain why they did not observe a regenerative response in flies. Typically, 30–50% of treated flies showed response in our assay. eLife Sciences Publications, Ltd 2023-06-22 /pmc/articles/PMC10287153/ /pubmed/37347515 http://dx.doi.org/10.7554/eLife.85370 Text en © 2023, Li et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Evolutionary Biology
Li, Yutian
Sarma, Anish A
Lee, Iris T
Tan, Fayth Hui
Abrams, Michael J
Condiotte, Zevin J
Heithe, Martin
Raffiee, Misha
Dabiri, John O
Gold, David A
Goentoro, Lea
Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'
title Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'
title_full Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'
title_fullStr Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'
title_full_unstemmed Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'
title_short Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'
title_sort response to comment on 'a conserved strategy for inducing appendage regeneration in moon jellyfish, drosophila, and mice'
topic Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287153/
https://www.ncbi.nlm.nih.gov/pubmed/37347515
http://dx.doi.org/10.7554/eLife.85370
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