Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq

Osteosarcoma (OS) is a primary bone tumor with high malignancy and the mechanism of hematogenous metastasis in OS is still not clear. The plasma exosomes derived from osteosarcoma play a key role in the process of tumor metastasis. Here, we established RNA-seq dataset for lncRNAs, circRNAs and mRNAs...

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Autores principales: Liu, Yun, Tang, Haijun, Li, Chong, Huang, Nenggan, Miao, Jifeng, Chen, Lin, Luo, Kai, Li, Feicui, Liu, Shangyu, Liao, Shijie, Feng, Wenyu, Zhan, Xinli, Xie, Tianyu, Tang, Wei, Wei, Qingjun, Lu, Jili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287625/
https://www.ncbi.nlm.nih.gov/pubmed/37349312
http://dx.doi.org/10.1038/s41597-023-02295-9
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author Liu, Yun
Tang, Haijun
Li, Chong
Huang, Nenggan
Miao, Jifeng
Chen, Lin
Luo, Kai
Li, Feicui
Liu, Shangyu
Liao, Shijie
Feng, Wenyu
Zhan, Xinli
Xie, Tianyu
Tang, Wei
Wei, Qingjun
Lu, Jili
author_facet Liu, Yun
Tang, Haijun
Li, Chong
Huang, Nenggan
Miao, Jifeng
Chen, Lin
Luo, Kai
Li, Feicui
Liu, Shangyu
Liao, Shijie
Feng, Wenyu
Zhan, Xinli
Xie, Tianyu
Tang, Wei
Wei, Qingjun
Lu, Jili
author_sort Liu, Yun
collection PubMed
description Osteosarcoma (OS) is a primary bone tumor with high malignancy and the mechanism of hematogenous metastasis in OS is still not clear. The plasma exosomes derived from osteosarcoma play a key role in the process of tumor metastasis. Here, we established RNA-seq dataset for lncRNAs, circRNAs and mRNAs in plasma exosomes from 10 OS patients and 5 healthy donors. A total of 329.52 Gb of clean data was obtained. Besides, 1754 lincRNAs, 7096 known and 1935 new circRNA was identified. Finally, gene expression profiles and differentially expressed genes (DEGs) were analyzed among these 15 samples. There were 331 DEGs of mRNA, 132 of lincRNA and 489 of circRNA was obtained, respectively. This data set provides a significant resource for relevant researchers to excavate potential dysregulated lncRNAs, circRNAs and mRNAs of plasma exosomes in OS versus normal conditions.
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spelling pubmed-102876252023-06-24 Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq Liu, Yun Tang, Haijun Li, Chong Huang, Nenggan Miao, Jifeng Chen, Lin Luo, Kai Li, Feicui Liu, Shangyu Liao, Shijie Feng, Wenyu Zhan, Xinli Xie, Tianyu Tang, Wei Wei, Qingjun Lu, Jili Sci Data Data Descriptor Osteosarcoma (OS) is a primary bone tumor with high malignancy and the mechanism of hematogenous metastasis in OS is still not clear. The plasma exosomes derived from osteosarcoma play a key role in the process of tumor metastasis. Here, we established RNA-seq dataset for lncRNAs, circRNAs and mRNAs in plasma exosomes from 10 OS patients and 5 healthy donors. A total of 329.52 Gb of clean data was obtained. Besides, 1754 lincRNAs, 7096 known and 1935 new circRNA was identified. Finally, gene expression profiles and differentially expressed genes (DEGs) were analyzed among these 15 samples. There were 331 DEGs of mRNA, 132 of lincRNA and 489 of circRNA was obtained, respectively. This data set provides a significant resource for relevant researchers to excavate potential dysregulated lncRNAs, circRNAs and mRNAs of plasma exosomes in OS versus normal conditions. Nature Publishing Group UK 2023-06-22 /pmc/articles/PMC10287625/ /pubmed/37349312 http://dx.doi.org/10.1038/s41597-023-02295-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Data Descriptor
Liu, Yun
Tang, Haijun
Li, Chong
Huang, Nenggan
Miao, Jifeng
Chen, Lin
Luo, Kai
Li, Feicui
Liu, Shangyu
Liao, Shijie
Feng, Wenyu
Zhan, Xinli
Xie, Tianyu
Tang, Wei
Wei, Qingjun
Lu, Jili
Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
title Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
title_full Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
title_fullStr Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
title_full_unstemmed Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
title_short Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
title_sort long non-coding rna and circular rna and coding rna profiling of plasma exosomes of osteosarcoma by rna seq
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287625/
https://www.ncbi.nlm.nih.gov/pubmed/37349312
http://dx.doi.org/10.1038/s41597-023-02295-9
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