Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response

Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due in part to the expression of inhibitory molecules in the tumor microenvironment, leading t...

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Detalles Bibliográficos
Autores principales: Chen, Zhao, Lin, Changyou, Pei, Hong, Yuan, Xiaomei, Xu, Jia, Zou, Mingwei, Zhang, Xinyuan, Fossier, Amber, Liu, Meizhu, Goo, Seungah, Lei, Lei, Yang, Jia, Novick, Catherine, Xu, Jiqing, Ying, Ge, Zhou, Zhihong, Wu, Jianbo, Tang, Chunyi, Zhang, Wenying, Wang, Zhenping, Wang, Zhihao, Zhang, Huitang, Guo, Wenzhong, Hu, Qidong, Ji, Henry, Chen, Runqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287668/
https://www.ncbi.nlm.nih.gov/pubmed/37349298
http://dx.doi.org/10.1038/s41389-023-00480-4

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