Mycobacterium abscessus VapC5 toxin potentiates evasion of antibiotic killing by ribosome overproduction and activation of multiple resistance pathways

Mycobacterium abscessus (Mab) infections are inexplicably intractable to clearing after aggressive and lengthy treatment regimens. Here we discovered that acquisition of a single toxin-antitoxin system enables Mab to activate a phenotypic switch that enhances survival upon treatment with current fir...

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Detalles Bibliográficos
Autores principales: Troian, Eduardo A., Maldonado, Heather M., Chauhan, Unnati, Barth, Valdir C., Woychik, Nancy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287673/
https://www.ncbi.nlm.nih.gov/pubmed/37349306
http://dx.doi.org/10.1038/s41467-023-38844-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287673/
https://www.ncbi.nlm.nih.gov/pubmed/37349306
http://dx.doi.org/10.1038/s41467-023-38844-4

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