Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo

Only praziquantel is available for treating schistosomiasis, a disease affecting more than 200 million people. Praziquantel-resistant worms have been selected for in the lab and low cure rates from mass drug administration programs suggest that resistance is evolving in the field. Thioredoxin glutat...

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Detalles Bibliográficos
Autores principales: Petukhova, Valentina Z., Aboagye, Sammy Y., Ardini, Matteo, Lullo, Rachel P., Fata, Francesca, Byrne, Margaret E., Gabriele, Federica, Martin, Lucy M., Harding, Luke N. M., Gone, Vamshikrishna, Dangi, Bikash, Lantvit, Daniel D., Nikolic, Dejan, Ippoliti, Rodolfo, Effantin, Grégory, Ling, Wai Li, Johnson, Jeremy J., Thatcher, Gregory R. J., Angelucci, Francesco, Williams, David L., Petukhov, Pavel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287695/
https://www.ncbi.nlm.nih.gov/pubmed/37349300
http://dx.doi.org/10.1038/s41467-023-39444-y

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