Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections

Agents that can simultaneously activate latent HIV, increase immune activation and enhance the killing of latently-infected cells represent promising approaches for HIV cure. Here, we develop and evaluate a trispecific antibody (Ab), N6/αCD3-αCD28, that targets three independent proteins: (1) the HI...

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Detalles Bibliográficos
Autores principales: Promsote, Wanwisa, Xu, Ling, Hataye, Jason, Fabozzi, Giulia, March, Kylie, Almasri, Cassandra G., DeMouth, Megan E., Lovelace, Sarah E., Talana, Chloe Adrienna, Doria-Rose, Nicole A., McKee, Krisha, Hait, Sabrina Helmold, Casazza, Joseph P., Ambrozak, David, Beninga, Jochen, Rao, Ercole, Furtmann, Norbert, Birkenfeld, Joerg, McCarthy, Elizabeth, Todd, John-Paul, Petrovas, Constantinos, Connors, Mark, Hebert, Andrew T., Beck, Jeremy, Shen, Junqing, Zhang, Bailin, Levit, Mikhail, Wei, Ronnie R., Yang, Zhi-yong, Pegu, Amarendra, Mascola, John R., Nabel, Gary J., Koup, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287722/
https://www.ncbi.nlm.nih.gov/pubmed/37349337
http://dx.doi.org/10.1038/s41467-023-39265-z

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