Time-dependent recruitment of GAF, ISGF3 and IRF1 complexes shapes IFNα and IFNγ-activated transcriptional responses and explains mechanistic and functional overlap

To understand in detail the transcriptional and functional overlap of IFN-I- and IFN-II-activated responses, we used an integrative RNAseq-ChIPseq approach in Huh7.5 cells and characterized the genome-wide role of pSTAT1, pSTAT2, IRF9 and IRF1 in time-dependent ISG expression. For the first time, ou...

Descripción completa

Detalles Bibliográficos
Autores principales: Sekrecka, Agata, Kluzek, Katarzyna, Sekrecki, Michal, Boroujeni, Mahdi Eskandarian, Hassani, Sanaz, Yamauchi, Shota, Sada, Kiyonao, Wesoly, Joanna, Bluyssen, Hans A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287828/
https://www.ncbi.nlm.nih.gov/pubmed/37347298
http://dx.doi.org/10.1007/s00018-023-04830-8

Ejemplares similares

Ejemplares similares