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Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry
INTRODUCTION: This study aimed to examine the performance of binocular chromatic pupillometry for the objective and rapid detection of primary open-angle glaucoma (POAG), and to explore the association between pupillary light response (PLR) features and structural glaucomatous macular damage. METHOD...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287851/ https://www.ncbi.nlm.nih.gov/pubmed/37284935 http://dx.doi.org/10.1007/s40123-023-00738-5 |
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author | Quan, Yadan Duan, Huiyu Zhan, Zongyi Shen, Yuening Lin, Rui Liu, Tingting Zhang, Ting Wu, Jihong Huang, Jing Zhai, Guangtao Song, Xuefei Zhou, Yixiong Sun, Xinghuai |
author_facet | Quan, Yadan Duan, Huiyu Zhan, Zongyi Shen, Yuening Lin, Rui Liu, Tingting Zhang, Ting Wu, Jihong Huang, Jing Zhai, Guangtao Song, Xuefei Zhou, Yixiong Sun, Xinghuai |
author_sort | Quan, Yadan |
collection | PubMed |
description | INTRODUCTION: This study aimed to examine the performance of binocular chromatic pupillometry for the objective and rapid detection of primary open-angle glaucoma (POAG), and to explore the association between pupillary light response (PLR) features and structural glaucomatous macular damage. METHODS: Forty-six patients (mean age 41.00 ± 13.03 years) with POAG and 23 healthy controls (mean age 42.00 ± 11.08 years) were enrolled. All participants underwent sequenced PLR tests of full-field, superior/inferior quadrant-field chromatic stimuli using a binocular head-mounted pupillometer. The constricting amplitude, velocity, and time to max constriction/dilation, and the post-illumination pupil response (PIPR) were analyzed. The inner retina thickness and volume measurements were determined by spectral domain optical coherence tomography. RESULTS: In the full-field stimulus experiment, time to pupil dilation was inversely correlated with perifoveal thickness (r = − 0.429, P < 0.001) and perifoveal volume (r = − 0.364, P < 0.001). Dilation time (AUC 0.833) showed good diagnostic performance, followed by the constriction amplitude (AUC 0.681) and PIPR (AUC 0.620). In the superior quadrant-field stimulus experiment, time of pupil dilation negatively correlated with inferior perifoveal thickness (r = − 0.451, P < 0.001) and inferior perifoveal volume (r = − 0.417, P < 0.001). The dilation time in response to the superior quadrant-field stimulus showed the best diagnostic performance (AUC 0.909). In the inferior quadrant-field stimulus experiment, time to pupil dilation (P < 0.001) correlated well with superior perifoveal thickness (r = − 0.299, P < 0.001) and superior perifoveal volume (r = − 0.304, P < 0.001). CONCLUSION: The use of chromatic pupillometry offers a patient-friendly and objective approach to detect POAG, while the impairment of PLR features may serve as a potential indicator of structural macular damage. |
format | Online Article Text |
id | pubmed-10287851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-102878512023-06-24 Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry Quan, Yadan Duan, Huiyu Zhan, Zongyi Shen, Yuening Lin, Rui Liu, Tingting Zhang, Ting Wu, Jihong Huang, Jing Zhai, Guangtao Song, Xuefei Zhou, Yixiong Sun, Xinghuai Ophthalmol Ther Original Research INTRODUCTION: This study aimed to examine the performance of binocular chromatic pupillometry for the objective and rapid detection of primary open-angle glaucoma (POAG), and to explore the association between pupillary light response (PLR) features and structural glaucomatous macular damage. METHODS: Forty-six patients (mean age 41.00 ± 13.03 years) with POAG and 23 healthy controls (mean age 42.00 ± 11.08 years) were enrolled. All participants underwent sequenced PLR tests of full-field, superior/inferior quadrant-field chromatic stimuli using a binocular head-mounted pupillometer. The constricting amplitude, velocity, and time to max constriction/dilation, and the post-illumination pupil response (PIPR) were analyzed. The inner retina thickness and volume measurements were determined by spectral domain optical coherence tomography. RESULTS: In the full-field stimulus experiment, time to pupil dilation was inversely correlated with perifoveal thickness (r = − 0.429, P < 0.001) and perifoveal volume (r = − 0.364, P < 0.001). Dilation time (AUC 0.833) showed good diagnostic performance, followed by the constriction amplitude (AUC 0.681) and PIPR (AUC 0.620). In the superior quadrant-field stimulus experiment, time of pupil dilation negatively correlated with inferior perifoveal thickness (r = − 0.451, P < 0.001) and inferior perifoveal volume (r = − 0.417, P < 0.001). The dilation time in response to the superior quadrant-field stimulus showed the best diagnostic performance (AUC 0.909). In the inferior quadrant-field stimulus experiment, time to pupil dilation (P < 0.001) correlated well with superior perifoveal thickness (r = − 0.299, P < 0.001) and superior perifoveal volume (r = − 0.304, P < 0.001). CONCLUSION: The use of chromatic pupillometry offers a patient-friendly and objective approach to detect POAG, while the impairment of PLR features may serve as a potential indicator of structural macular damage. Springer Healthcare 2023-06-07 2023-08 /pmc/articles/PMC10287851/ /pubmed/37284935 http://dx.doi.org/10.1007/s40123-023-00738-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Quan, Yadan Duan, Huiyu Zhan, Zongyi Shen, Yuening Lin, Rui Liu, Tingting Zhang, Ting Wu, Jihong Huang, Jing Zhai, Guangtao Song, Xuefei Zhou, Yixiong Sun, Xinghuai Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry |
title | Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry |
title_full | Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry |
title_fullStr | Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry |
title_full_unstemmed | Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry |
title_short | Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry |
title_sort | evaluation of the glaucomatous macular damage by chromatic pupillometry |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287851/ https://www.ncbi.nlm.nih.gov/pubmed/37284935 http://dx.doi.org/10.1007/s40123-023-00738-5 |
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