Cargando…
Longitudinal Assessment of the Choroidal Vascularity Index in Eyes with Branch Retinal Vein Occlusion-Associated Cystoid Macular Edema
INTRODUCTION: Cystoid macular edema (CME) is the most common cause of central vision loss in eyes with branch retinal vein occlusion (BRVO eyes). In recent literature, choroidal vascularity index (CVI) has been proposed to be an enhanced depth imaging optical coherence tomography (EDI-OCT) metric th...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287880/ https://www.ncbi.nlm.nih.gov/pubmed/37221425 http://dx.doi.org/10.1007/s40123-023-00731-y |
_version_ | 1785061962673029120 |
---|---|
author | Pant, Praruj Kundu, Anita Rathinavelu, Jay K. Wei, Xin Agrawal, Rupesh Stinnett, Sandra S. Kim, Jane S. Thomas, Akshay S. Fekrat, Sharon |
author_facet | Pant, Praruj Kundu, Anita Rathinavelu, Jay K. Wei, Xin Agrawal, Rupesh Stinnett, Sandra S. Kim, Jane S. Thomas, Akshay S. Fekrat, Sharon |
author_sort | Pant, Praruj |
collection | PubMed |
description | INTRODUCTION: Cystoid macular edema (CME) is the most common cause of central vision loss in eyes with branch retinal vein occlusion (BRVO eyes). In recent literature, choroidal vascularity index (CVI) has been proposed to be an enhanced depth imaging optical coherence tomography (EDI-OCT) metric that may help characterize choroidal vascular changes in the setting of retinal ischemia, and potentially prognose visual outcomes and treatment patterns for patients with BRVO-related CME. This study sought to further characterize choroidal vascular changes in BRVO by comparing the CVI, subfoveal choroidal thickness (SFCT), and central subfield thickness (CST) in BRVO eyes with CME compared to unaffected fellow eyes. METHODS: This was a retrospective cohort study. Subjects included treatment-naïve BRVO eyes with CME diagnosed within 3 months of onset of symptoms and unaffected fellow eyes. EDI-OCT images were collected at baseline and at the 12-month follow-up visit. CVI, SFCT, and CST were measured. Demographics, treatment patterns, and best-corrected visual acuity (VA) were abstracted. Median CVI, SFCT, CST, and VA were compared between the two cohorts. Longitudinal relationships between these variables were analyzed. RESULTS: A total of 52 treatment-naïve eyes with BRVO and CME and 48 unaffected fellow eyes were identified. Baseline CVI was lower in eyes with BRVO than in fellow eyes (64.7% vs. 66.4%, P = 0.003). At 12 months, there was no difference in CVI between BRVO eyes and fellow eyes (65.7% vs 65.8%, P = 0.536). In BRVO eyes, there was a strong correlation between reduced CST and improved VA over the 12-month study period (r = 0.671, P < 0.001). CONCLUSION: There are differences in CVI in treatment-naïve BRVO eyes with CME at presentation compared to fellow eyes, but these differences resolve over time. Anatomic changes in macular thickness in BRVO eyes with CME may be correlated with VA outcomes. |
format | Online Article Text |
id | pubmed-10287880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-102878802023-06-24 Longitudinal Assessment of the Choroidal Vascularity Index in Eyes with Branch Retinal Vein Occlusion-Associated Cystoid Macular Edema Pant, Praruj Kundu, Anita Rathinavelu, Jay K. Wei, Xin Agrawal, Rupesh Stinnett, Sandra S. Kim, Jane S. Thomas, Akshay S. Fekrat, Sharon Ophthalmol Ther Original Research INTRODUCTION: Cystoid macular edema (CME) is the most common cause of central vision loss in eyes with branch retinal vein occlusion (BRVO eyes). In recent literature, choroidal vascularity index (CVI) has been proposed to be an enhanced depth imaging optical coherence tomography (EDI-OCT) metric that may help characterize choroidal vascular changes in the setting of retinal ischemia, and potentially prognose visual outcomes and treatment patterns for patients with BRVO-related CME. This study sought to further characterize choroidal vascular changes in BRVO by comparing the CVI, subfoveal choroidal thickness (SFCT), and central subfield thickness (CST) in BRVO eyes with CME compared to unaffected fellow eyes. METHODS: This was a retrospective cohort study. Subjects included treatment-naïve BRVO eyes with CME diagnosed within 3 months of onset of symptoms and unaffected fellow eyes. EDI-OCT images were collected at baseline and at the 12-month follow-up visit. CVI, SFCT, and CST were measured. Demographics, treatment patterns, and best-corrected visual acuity (VA) were abstracted. Median CVI, SFCT, CST, and VA were compared between the two cohorts. Longitudinal relationships between these variables were analyzed. RESULTS: A total of 52 treatment-naïve eyes with BRVO and CME and 48 unaffected fellow eyes were identified. Baseline CVI was lower in eyes with BRVO than in fellow eyes (64.7% vs. 66.4%, P = 0.003). At 12 months, there was no difference in CVI between BRVO eyes and fellow eyes (65.7% vs 65.8%, P = 0.536). In BRVO eyes, there was a strong correlation between reduced CST and improved VA over the 12-month study period (r = 0.671, P < 0.001). CONCLUSION: There are differences in CVI in treatment-naïve BRVO eyes with CME at presentation compared to fellow eyes, but these differences resolve over time. Anatomic changes in macular thickness in BRVO eyes with CME may be correlated with VA outcomes. Springer Healthcare 2023-05-23 2023-08 /pmc/articles/PMC10287880/ /pubmed/37221425 http://dx.doi.org/10.1007/s40123-023-00731-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Pant, Praruj Kundu, Anita Rathinavelu, Jay K. Wei, Xin Agrawal, Rupesh Stinnett, Sandra S. Kim, Jane S. Thomas, Akshay S. Fekrat, Sharon Longitudinal Assessment of the Choroidal Vascularity Index in Eyes with Branch Retinal Vein Occlusion-Associated Cystoid Macular Edema |
title | Longitudinal Assessment of the Choroidal Vascularity Index in Eyes with Branch Retinal Vein Occlusion-Associated Cystoid Macular Edema |
title_full | Longitudinal Assessment of the Choroidal Vascularity Index in Eyes with Branch Retinal Vein Occlusion-Associated Cystoid Macular Edema |
title_fullStr | Longitudinal Assessment of the Choroidal Vascularity Index in Eyes with Branch Retinal Vein Occlusion-Associated Cystoid Macular Edema |
title_full_unstemmed | Longitudinal Assessment of the Choroidal Vascularity Index in Eyes with Branch Retinal Vein Occlusion-Associated Cystoid Macular Edema |
title_short | Longitudinal Assessment of the Choroidal Vascularity Index in Eyes with Branch Retinal Vein Occlusion-Associated Cystoid Macular Edema |
title_sort | longitudinal assessment of the choroidal vascularity index in eyes with branch retinal vein occlusion-associated cystoid macular edema |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287880/ https://www.ncbi.nlm.nih.gov/pubmed/37221425 http://dx.doi.org/10.1007/s40123-023-00731-y |
work_keys_str_mv | AT pantpraruj longitudinalassessmentofthechoroidalvascularityindexineyeswithbranchretinalveinocclusionassociatedcystoidmacularedema AT kunduanita longitudinalassessmentofthechoroidalvascularityindexineyeswithbranchretinalveinocclusionassociatedcystoidmacularedema AT rathinavelujayk longitudinalassessmentofthechoroidalvascularityindexineyeswithbranchretinalveinocclusionassociatedcystoidmacularedema AT weixin longitudinalassessmentofthechoroidalvascularityindexineyeswithbranchretinalveinocclusionassociatedcystoidmacularedema AT agrawalrupesh longitudinalassessmentofthechoroidalvascularityindexineyeswithbranchretinalveinocclusionassociatedcystoidmacularedema AT stinnettsandras longitudinalassessmentofthechoroidalvascularityindexineyeswithbranchretinalveinocclusionassociatedcystoidmacularedema AT kimjanes longitudinalassessmentofthechoroidalvascularityindexineyeswithbranchretinalveinocclusionassociatedcystoidmacularedema AT thomasakshays longitudinalassessmentofthechoroidalvascularityindexineyeswithbranchretinalveinocclusionassociatedcystoidmacularedema AT fekratsharon longitudinalassessmentofthechoroidalvascularityindexineyeswithbranchretinalveinocclusionassociatedcystoidmacularedema |