ATXN3 controls DNA replication and transcription by regulating chromatin structure

The deubiquitinating enzyme Ataxin-3 (ATXN3) contains a polyglutamine (PolyQ) region, the expansion of which causes spinocerebellar ataxia type-3 (SCA3). ATXN3 has multiple functions, such as regulating transcription or controlling genomic stability after DNA damage. Here we report the role of ATXN3...

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Detalles Bibliográficos
Autores principales: Hernández‐Carralero, Esperanza, Cabrera, Elisa, Rodríguez-Torres, Gara, Hernández-Reyes, Yeray, Singh, Abhay N, Santa-María, Cristina, Fernández-Justel, José Miguel, Janssens, Roel C, Marteijn, Jurgen A, Evert, Bernd O, Mailand, Niels, Gómez, María, Ramadan, Kristijan, Smits, Veronique A J, Freire, Raimundo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287915/
https://www.ncbi.nlm.nih.gov/pubmed/36971114
http://dx.doi.org/10.1093/nar/gkad212

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