RBBP4 is an epigenetic barrier for the induced transition of pluripotent stem cells into totipotent 2C-like cells

Cellular totipotency is critical for whole-organism generation, yet how totipotency is established remains poorly illustrated. Abundant transposable elements (TEs) are activated in totipotent cells, which is critical for embryonic totipotency. Here, we show that the histone chaperone RBBP4, but not...

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Detalles Bibliográficos
Autores principales: Ping, Wangfang, Sheng, Yingliang, Hu, Gongcheng, Zhong, Hongxin, Li, Yaoyi, Liu, YanJiang, Luo, Wei, Yan, Chenghong, Wen, Yulin, Wang, Xinxiu, Li, Qing, Guo, Rong, Zhang, Jie, Liu, Ake, Pan, Guangjin, Yao, Hongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287929/
https://www.ncbi.nlm.nih.gov/pubmed/37021556
http://dx.doi.org/10.1093/nar/gkad219

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