Self-delivery of TIGIT-blocking scFv enhances CAR-T immunotherapy in solid tumors

Chimeric antigen receptor T cell therapy has become an important immunotherapeutic tool for overcoming cancers. However, the efficacy of CAR-T cell therapy in solid tumors is relatively poor due to the complexity of the tumor microenvironment and inhibitory immune checkpoints. TIGIT on the surface o...

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Detalles Bibliográficos
Autores principales: Yang, Fan, Zhang, Fan, Ji, Feng, Chen, Jiannan, Li, Jun, Chen, Zhengliang, Hu, Zhigang, Guo, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287952/
https://www.ncbi.nlm.nih.gov/pubmed/37359558
http://dx.doi.org/10.3389/fimmu.2023.1175920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287952/
https://www.ncbi.nlm.nih.gov/pubmed/37359558
http://dx.doi.org/10.3389/fimmu.2023.1175920

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