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Conformational dynamics of RNA G(4)C(2) and G(2)C(4) repeat expansions causing ALS/FTD using NMR and molecular dynamics studies

G(4)C(2) and G(2)C(4) repeat expansions in chromosome 9 open reading frame 72 (C9orf72) are the most common cause of genetically defined amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), or c9ALS/FTD. The gene is bidirectionally transcribed, producing G(4)C(2) repeats [r(G(4)C(2...

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Detalles Bibliográficos
Autores principales:	Taghavi, Amirhossein, Baisden, Jared T, Childs-Disney, Jessica L, Yildirim, Ilyas, Disney, Matthew D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287959/ https://www.ncbi.nlm.nih.gov/pubmed/37216594 http://dx.doi.org/10.1093/nar/gkad403

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