Cargando…
The effect of neural pre-stimulus oscillations on post-stimulus somatosensory event-related potentials in disorders of consciousness
Brain activity of people in a disorder of consciousness (DoC) is diffuse and different from healthy people. In order to get a better understanding of their cognitive processes and functions, electroencephalographic activity has often been examined in patients with DoC, including detection of event-r...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287968/ https://www.ncbi.nlm.nih.gov/pubmed/37360157 http://dx.doi.org/10.3389/fnins.2023.1179228 |
_version_ | 1785061980406546432 |
---|---|
author | Lindenbaum, Laura Steppacher, Inga Mehlmann, Alexandra Kissler, Johanna Maria |
author_facet | Lindenbaum, Laura Steppacher, Inga Mehlmann, Alexandra Kissler, Johanna Maria |
author_sort | Lindenbaum, Laura |
collection | PubMed |
description | Brain activity of people in a disorder of consciousness (DoC) is diffuse and different from healthy people. In order to get a better understanding of their cognitive processes and functions, electroencephalographic activity has often been examined in patients with DoC, including detection of event-related potentials (ERPs) and spectral power analysis. However, the relationship between pre-stimulus oscillations and post-stimulus ERPs has rarely been explored in DoC, although it is known from healthy participants that pre-stimulus oscillations predispose subsequent stimulus detection. Here, we examine to what extent pre-stimulus electroencephalography band power in DoC relates to post-stimulus ERPs in a similar way as previously documented in healthy people. 14 DoC patients in an unresponsive wakefulness syndrome (UWS, N = 2) or a minimally conscious state (MCS, N = 12) participated in this study. In an active oddball paradigm patients received vibrotactile stimuli. Significant post-stimulus differences between brain responses to deviant and standard stimulation could be found in six MCS patients (42.86%). Regarding relative pre-stimulus frequency bands, delta oscillations predominated in most patients, followed by theta and alpha, although two patients showed a relatively normal power spectrum. The statistical analysis of the relationship between pre-stimulus power and post-stimulus event-related brain response showed multiple significant correlations in five out of the six patients. Individual results sometimes showed similar correlation patterns as in healthy subjects primarily between the relative pre-stimulus alpha power and post-stimulus variables in later time-intervals. However, opposite effects were also found, indicating high inter-individual variability in DoC patients´ functional brain activity. Future studies should determine on an individual level to what extent the relationship between pre- and post-stimulus brain activity could relate to the course of the disorder. |
format | Online Article Text |
id | pubmed-10287968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102879682023-06-24 The effect of neural pre-stimulus oscillations on post-stimulus somatosensory event-related potentials in disorders of consciousness Lindenbaum, Laura Steppacher, Inga Mehlmann, Alexandra Kissler, Johanna Maria Front Neurosci Neuroscience Brain activity of people in a disorder of consciousness (DoC) is diffuse and different from healthy people. In order to get a better understanding of their cognitive processes and functions, electroencephalographic activity has often been examined in patients with DoC, including detection of event-related potentials (ERPs) and spectral power analysis. However, the relationship between pre-stimulus oscillations and post-stimulus ERPs has rarely been explored in DoC, although it is known from healthy participants that pre-stimulus oscillations predispose subsequent stimulus detection. Here, we examine to what extent pre-stimulus electroencephalography band power in DoC relates to post-stimulus ERPs in a similar way as previously documented in healthy people. 14 DoC patients in an unresponsive wakefulness syndrome (UWS, N = 2) or a minimally conscious state (MCS, N = 12) participated in this study. In an active oddball paradigm patients received vibrotactile stimuli. Significant post-stimulus differences between brain responses to deviant and standard stimulation could be found in six MCS patients (42.86%). Regarding relative pre-stimulus frequency bands, delta oscillations predominated in most patients, followed by theta and alpha, although two patients showed a relatively normal power spectrum. The statistical analysis of the relationship between pre-stimulus power and post-stimulus event-related brain response showed multiple significant correlations in five out of the six patients. Individual results sometimes showed similar correlation patterns as in healthy subjects primarily between the relative pre-stimulus alpha power and post-stimulus variables in later time-intervals. However, opposite effects were also found, indicating high inter-individual variability in DoC patients´ functional brain activity. Future studies should determine on an individual level to what extent the relationship between pre- and post-stimulus brain activity could relate to the course of the disorder. Frontiers Media S.A. 2023-06-09 /pmc/articles/PMC10287968/ /pubmed/37360157 http://dx.doi.org/10.3389/fnins.2023.1179228 Text en Copyright © 2023 Lindenbaum, Steppacher, Mehlmann and Kissler. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Lindenbaum, Laura Steppacher, Inga Mehlmann, Alexandra Kissler, Johanna Maria The effect of neural pre-stimulus oscillations on post-stimulus somatosensory event-related potentials in disorders of consciousness |
title | The effect of neural pre-stimulus oscillations on post-stimulus somatosensory event-related potentials in disorders of consciousness |
title_full | The effect of neural pre-stimulus oscillations on post-stimulus somatosensory event-related potentials in disorders of consciousness |
title_fullStr | The effect of neural pre-stimulus oscillations on post-stimulus somatosensory event-related potentials in disorders of consciousness |
title_full_unstemmed | The effect of neural pre-stimulus oscillations on post-stimulus somatosensory event-related potentials in disorders of consciousness |
title_short | The effect of neural pre-stimulus oscillations on post-stimulus somatosensory event-related potentials in disorders of consciousness |
title_sort | effect of neural pre-stimulus oscillations on post-stimulus somatosensory event-related potentials in disorders of consciousness |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287968/ https://www.ncbi.nlm.nih.gov/pubmed/37360157 http://dx.doi.org/10.3389/fnins.2023.1179228 |
work_keys_str_mv | AT lindenbaumlaura theeffectofneuralprestimulusoscillationsonpoststimulussomatosensoryeventrelatedpotentialsindisordersofconsciousness AT steppacheringa theeffectofneuralprestimulusoscillationsonpoststimulussomatosensoryeventrelatedpotentialsindisordersofconsciousness AT mehlmannalexandra theeffectofneuralprestimulusoscillationsonpoststimulussomatosensoryeventrelatedpotentialsindisordersofconsciousness AT kisslerjohannamaria theeffectofneuralprestimulusoscillationsonpoststimulussomatosensoryeventrelatedpotentialsindisordersofconsciousness AT lindenbaumlaura effectofneuralprestimulusoscillationsonpoststimulussomatosensoryeventrelatedpotentialsindisordersofconsciousness AT steppacheringa effectofneuralprestimulusoscillationsonpoststimulussomatosensoryeventrelatedpotentialsindisordersofconsciousness AT mehlmannalexandra effectofneuralprestimulusoscillationsonpoststimulussomatosensoryeventrelatedpotentialsindisordersofconsciousness AT kisslerjohannamaria effectofneuralprestimulusoscillationsonpoststimulussomatosensoryeventrelatedpotentialsindisordersofconsciousness |