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Harnessing the potential of probiotics in the treatment of alcoholic liver disorders
In the current scenario, prolonged consumption of alcohol across the globe is upsurging an appreciable number of patients with the risk of alcohol-associated liver diseases. According to the recent report, the gut-liver axis is crucial in the progression of alcohol-induced liver diseases, including...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287977/ https://www.ncbi.nlm.nih.gov/pubmed/37361234 http://dx.doi.org/10.3389/fphar.2023.1212742 |
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author | Mishra, Garima Singh, Pradeep Molla, Mulugeta Yimer, Yohannes Shumet Dinda, Subas Chandra Chandra, Phool Singh, Bhuvnesh Kumar Dagnew, Samuel Berihun Assefa, Abraham Nigussie Ewunetie, Amien |
author_facet | Mishra, Garima Singh, Pradeep Molla, Mulugeta Yimer, Yohannes Shumet Dinda, Subas Chandra Chandra, Phool Singh, Bhuvnesh Kumar Dagnew, Samuel Berihun Assefa, Abraham Nigussie Ewunetie, Amien |
author_sort | Mishra, Garima |
collection | PubMed |
description | In the current scenario, prolonged consumption of alcohol across the globe is upsurging an appreciable number of patients with the risk of alcohol-associated liver diseases. According to the recent report, the gut-liver axis is crucial in the progression of alcohol-induced liver diseases, including steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Despite several factors associated with alcoholic liver diseases, the complexity of the gut microflora and its great interaction with the liver have become a fascinating area for researchers due to the high exposure of the liver to free radicals, bacterial endotoxins, lipopolysaccharides, inflammatory markers, etc. Undoubtedly, alcohol-induced gut microbiota imbalance stimulates dysbiosis, disrupts the intestinal barrier function, and trigger immune as well as inflammatory responses which further aggravate hepatic injury. Since currently available drugs to mitigate liver disorders have significant side effects, hence, probiotics have been widely researched to alleviate alcohol-associated liver diseases and to improve liver health. A broad range of probiotic bacteria like Lactobacillus, Bifidobacteria, Escherichia coli, Sacchromyces, and Lactococcus are used to reduce or halt the progression of alcohol-associated liver diseases. Several underlying mechanisms, including alteration of the gut microbiome, modulation of intestinal barrier function and immune response, reduction in the level of endotoxins, and bacterial translocation, have been implicated through which probiotics can effectively suppress the occurrence of alcohol-induced liver disorders. This review addresses the therapeutic applications of probiotics in the treatment of alcohol-associated liver diseases. Novel insights into the mechanisms by which probiotics prevent alcohol-associated liver diseases have also been elaborated. |
format | Online Article Text |
id | pubmed-10287977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102879772023-06-24 Harnessing the potential of probiotics in the treatment of alcoholic liver disorders Mishra, Garima Singh, Pradeep Molla, Mulugeta Yimer, Yohannes Shumet Dinda, Subas Chandra Chandra, Phool Singh, Bhuvnesh Kumar Dagnew, Samuel Berihun Assefa, Abraham Nigussie Ewunetie, Amien Front Pharmacol Pharmacology In the current scenario, prolonged consumption of alcohol across the globe is upsurging an appreciable number of patients with the risk of alcohol-associated liver diseases. According to the recent report, the gut-liver axis is crucial in the progression of alcohol-induced liver diseases, including steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Despite several factors associated with alcoholic liver diseases, the complexity of the gut microflora and its great interaction with the liver have become a fascinating area for researchers due to the high exposure of the liver to free radicals, bacterial endotoxins, lipopolysaccharides, inflammatory markers, etc. Undoubtedly, alcohol-induced gut microbiota imbalance stimulates dysbiosis, disrupts the intestinal barrier function, and trigger immune as well as inflammatory responses which further aggravate hepatic injury. Since currently available drugs to mitigate liver disorders have significant side effects, hence, probiotics have been widely researched to alleviate alcohol-associated liver diseases and to improve liver health. A broad range of probiotic bacteria like Lactobacillus, Bifidobacteria, Escherichia coli, Sacchromyces, and Lactococcus are used to reduce or halt the progression of alcohol-associated liver diseases. Several underlying mechanisms, including alteration of the gut microbiome, modulation of intestinal barrier function and immune response, reduction in the level of endotoxins, and bacterial translocation, have been implicated through which probiotics can effectively suppress the occurrence of alcohol-induced liver disorders. This review addresses the therapeutic applications of probiotics in the treatment of alcohol-associated liver diseases. Novel insights into the mechanisms by which probiotics prevent alcohol-associated liver diseases have also been elaborated. Frontiers Media S.A. 2023-06-09 /pmc/articles/PMC10287977/ /pubmed/37361234 http://dx.doi.org/10.3389/fphar.2023.1212742 Text en Copyright © 2023 Mishra, Singh, Molla, Yimer, Dinda, Chandra, Singh, Dagnew, Assefa and Ewunetie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Mishra, Garima Singh, Pradeep Molla, Mulugeta Yimer, Yohannes Shumet Dinda, Subas Chandra Chandra, Phool Singh, Bhuvnesh Kumar Dagnew, Samuel Berihun Assefa, Abraham Nigussie Ewunetie, Amien Harnessing the potential of probiotics in the treatment of alcoholic liver disorders |
title | Harnessing the potential of probiotics in the treatment of alcoholic liver disorders |
title_full | Harnessing the potential of probiotics in the treatment of alcoholic liver disorders |
title_fullStr | Harnessing the potential of probiotics in the treatment of alcoholic liver disorders |
title_full_unstemmed | Harnessing the potential of probiotics in the treatment of alcoholic liver disorders |
title_short | Harnessing the potential of probiotics in the treatment of alcoholic liver disorders |
title_sort | harnessing the potential of probiotics in the treatment of alcoholic liver disorders |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287977/ https://www.ncbi.nlm.nih.gov/pubmed/37361234 http://dx.doi.org/10.3389/fphar.2023.1212742 |
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