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Isolated Hodgkin lymphoma of the intracranial dura: A case report and review of the literature
Primary dural Hodgkin lymphoma (PDHL) is an extremely rare subset of Hodgkin lymphoma (HL). Its existence is controversial, as Hodgkin lymphoma is not traditionally thought to arise from the central nervous system (CNS) or its meninges and only 0.02% of patients with Hodgkin lymphoma have any CNS in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288013/ https://www.ncbi.nlm.nih.gov/pubmed/37361649 http://dx.doi.org/10.1002/ccr3.7562 |
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author | Kanagalingam, Tharsan Velker, Vikram Pejhan, Shervin Zhang, Qi Mangel, Joy Young, Sympascho |
author_facet | Kanagalingam, Tharsan Velker, Vikram Pejhan, Shervin Zhang, Qi Mangel, Joy Young, Sympascho |
author_sort | Kanagalingam, Tharsan |
collection | PubMed |
description | Primary dural Hodgkin lymphoma (PDHL) is an extremely rare subset of Hodgkin lymphoma (HL). Its existence is controversial, as Hodgkin lymphoma is not traditionally thought to arise from the central nervous system (CNS) or its meninges and only 0.02% of patients with Hodgkin lymphoma have any CNS involvement. We report a case of a 71‐year‐old Caucasian man who presented with progressive fatigue and sudden onset slurred speech, disorientation, and memory loss. Brain imaging identified a large extra‐axial right frontal mass, and he underwent urgent subtotal resection. Pathology and subsequent workup revealed Stage IAE classical Hodgkin lymphoma of the right frontal dura, with no extra‐cranial disease or leptomeningeal spread detected. The patient was subsequently treated with ABVD chemotherapy (completed 2.5 of 4 planned cycles) and 36 Gy in 20 fractions of consolidative involved‐site radiotherapy (ISRT). He has been followed for 5 years with no clinical or radiological signs of recurrence. This is the second confirmed case of intracranial PDHL reported in the literature, with the longest follow‐up for any case of PDHL. |
format | Online Article Text |
id | pubmed-10288013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102880132023-06-24 Isolated Hodgkin lymphoma of the intracranial dura: A case report and review of the literature Kanagalingam, Tharsan Velker, Vikram Pejhan, Shervin Zhang, Qi Mangel, Joy Young, Sympascho Clin Case Rep Case Report Primary dural Hodgkin lymphoma (PDHL) is an extremely rare subset of Hodgkin lymphoma (HL). Its existence is controversial, as Hodgkin lymphoma is not traditionally thought to arise from the central nervous system (CNS) or its meninges and only 0.02% of patients with Hodgkin lymphoma have any CNS involvement. We report a case of a 71‐year‐old Caucasian man who presented with progressive fatigue and sudden onset slurred speech, disorientation, and memory loss. Brain imaging identified a large extra‐axial right frontal mass, and he underwent urgent subtotal resection. Pathology and subsequent workup revealed Stage IAE classical Hodgkin lymphoma of the right frontal dura, with no extra‐cranial disease or leptomeningeal spread detected. The patient was subsequently treated with ABVD chemotherapy (completed 2.5 of 4 planned cycles) and 36 Gy in 20 fractions of consolidative involved‐site radiotherapy (ISRT). He has been followed for 5 years with no clinical or radiological signs of recurrence. This is the second confirmed case of intracranial PDHL reported in the literature, with the longest follow‐up for any case of PDHL. John Wiley and Sons Inc. 2023-06-22 /pmc/articles/PMC10288013/ /pubmed/37361649 http://dx.doi.org/10.1002/ccr3.7562 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kanagalingam, Tharsan Velker, Vikram Pejhan, Shervin Zhang, Qi Mangel, Joy Young, Sympascho Isolated Hodgkin lymphoma of the intracranial dura: A case report and review of the literature |
title | Isolated Hodgkin lymphoma of the intracranial dura: A case report and review of the literature |
title_full | Isolated Hodgkin lymphoma of the intracranial dura: A case report and review of the literature |
title_fullStr | Isolated Hodgkin lymphoma of the intracranial dura: A case report and review of the literature |
title_full_unstemmed | Isolated Hodgkin lymphoma of the intracranial dura: A case report and review of the literature |
title_short | Isolated Hodgkin lymphoma of the intracranial dura: A case report and review of the literature |
title_sort | isolated hodgkin lymphoma of the intracranial dura: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288013/ https://www.ncbi.nlm.nih.gov/pubmed/37361649 http://dx.doi.org/10.1002/ccr3.7562 |
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