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Role of breastfeeding on maternal and childhood cancers: An umbrella review of meta-analyses
BACKGROUND: Multiple studies and meta-analyses have claimed that breastfeeding is inversely correlated with maternal and childhood cancers. These results could either be causal or confounded by shared risk factors. By conducting an umbrella review, we aimed to consolidate the relationship between br...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Society of Global Health
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288171/ https://www.ncbi.nlm.nih.gov/pubmed/37350093 http://dx.doi.org/10.7189/jogh.13.04067 |
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author | Fan, Dazhi Xia, Qing Lin, Dongxin Ma, Yubo Rao, Jiaming Liu, Li Tang, Hai Xu, Tingting Li, Pengsheng Chen, Gengdong Zhou, Zixing Guo, Xiaoling Zhang, Zhifang Liu, Zhengping |
author_facet | Fan, Dazhi Xia, Qing Lin, Dongxin Ma, Yubo Rao, Jiaming Liu, Li Tang, Hai Xu, Tingting Li, Pengsheng Chen, Gengdong Zhou, Zixing Guo, Xiaoling Zhang, Zhifang Liu, Zhengping |
author_sort | Fan, Dazhi |
collection | PubMed |
description | BACKGROUND: Multiple studies and meta-analyses have claimed that breastfeeding is inversely correlated with maternal and childhood cancers. These results could either be causal or confounded by shared risk factors. By conducting an umbrella review, we aimed to consolidate the relationship between breastfeeding and maternal and childhood cancers. METHODS: We searched PubMed, Embase, Web of Science, Elsevier ScienceDirect, and Cochrane Library databases from inception to December 2022. Two reviewers independently extracted the data and assessed the quality of the studies using standardised forms. We considered two types of breastfeeding comparisons (“ever” vs “never” breastfeeding; and “longest” vs “shortest” duration). We estimated the pooled risk and 95% confidence interval (CI) for each meta-analysis. RESULTS: We included seventeen meta-analyses with 55 comparisons. There was an inverse correlation between breastfeeding and childhood leukaemia (pooled risk = 0.90, 95% CI = 0.81-0.99), neuroblastoma (pooled risk = 0.81, 95% CI = 0.71-0.93), maternal ovarian cancer (pooled risk = 0.76, CI = 0.71-0.81), breast cancer (pooled risk = 0.85, 95% CI = 0.82-0.88), and oesophageal cancer (pooled risk = 0.67, 95% CI = 0.54-0.81) for “ever” vs “never” breastfeeding; and with childhood leukaemia (pooled risk = 0.94, 95% CI = 0.89-0.98), and maternal ovarian cancer (pooled risk = 0.84, 95% CI = 0.78-0.90) and breast cancer (pooled risk = 0.92, 95% CI = 0.89-0.96) for “longest” vs “shortest” breastfeeding duration. CONCLUSIONS: We found evidence that breastfeeding may reduce the risk of maternal breast cancer, ovarian cancers, and childhood leukaemia, suggesting positive implications for influencing women’s decision in breastfeeding. REGISTRATION: PROSPERO (CRD42021255608). |
format | Online Article Text |
id | pubmed-10288171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | International Society of Global Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-102881712023-06-24 Role of breastfeeding on maternal and childhood cancers: An umbrella review of meta-analyses Fan, Dazhi Xia, Qing Lin, Dongxin Ma, Yubo Rao, Jiaming Liu, Li Tang, Hai Xu, Tingting Li, Pengsheng Chen, Gengdong Zhou, Zixing Guo, Xiaoling Zhang, Zhifang Liu, Zhengping J Glob Health Articles BACKGROUND: Multiple studies and meta-analyses have claimed that breastfeeding is inversely correlated with maternal and childhood cancers. These results could either be causal or confounded by shared risk factors. By conducting an umbrella review, we aimed to consolidate the relationship between breastfeeding and maternal and childhood cancers. METHODS: We searched PubMed, Embase, Web of Science, Elsevier ScienceDirect, and Cochrane Library databases from inception to December 2022. Two reviewers independently extracted the data and assessed the quality of the studies using standardised forms. We considered two types of breastfeeding comparisons (“ever” vs “never” breastfeeding; and “longest” vs “shortest” duration). We estimated the pooled risk and 95% confidence interval (CI) for each meta-analysis. RESULTS: We included seventeen meta-analyses with 55 comparisons. There was an inverse correlation between breastfeeding and childhood leukaemia (pooled risk = 0.90, 95% CI = 0.81-0.99), neuroblastoma (pooled risk = 0.81, 95% CI = 0.71-0.93), maternal ovarian cancer (pooled risk = 0.76, CI = 0.71-0.81), breast cancer (pooled risk = 0.85, 95% CI = 0.82-0.88), and oesophageal cancer (pooled risk = 0.67, 95% CI = 0.54-0.81) for “ever” vs “never” breastfeeding; and with childhood leukaemia (pooled risk = 0.94, 95% CI = 0.89-0.98), and maternal ovarian cancer (pooled risk = 0.84, 95% CI = 0.78-0.90) and breast cancer (pooled risk = 0.92, 95% CI = 0.89-0.96) for “longest” vs “shortest” breastfeeding duration. CONCLUSIONS: We found evidence that breastfeeding may reduce the risk of maternal breast cancer, ovarian cancers, and childhood leukaemia, suggesting positive implications for influencing women’s decision in breastfeeding. REGISTRATION: PROSPERO (CRD42021255608). International Society of Global Health 2023-06-23 /pmc/articles/PMC10288171/ /pubmed/37350093 http://dx.doi.org/10.7189/jogh.13.04067 Text en Copyright © 2023 by the Journal of Global Health. All rights reserved. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Articles Fan, Dazhi Xia, Qing Lin, Dongxin Ma, Yubo Rao, Jiaming Liu, Li Tang, Hai Xu, Tingting Li, Pengsheng Chen, Gengdong Zhou, Zixing Guo, Xiaoling Zhang, Zhifang Liu, Zhengping Role of breastfeeding on maternal and childhood cancers: An umbrella review of meta-analyses |
title | Role of breastfeeding on maternal and childhood cancers: An umbrella review of meta-analyses |
title_full | Role of breastfeeding on maternal and childhood cancers: An umbrella review of meta-analyses |
title_fullStr | Role of breastfeeding on maternal and childhood cancers: An umbrella review of meta-analyses |
title_full_unstemmed | Role of breastfeeding on maternal and childhood cancers: An umbrella review of meta-analyses |
title_short | Role of breastfeeding on maternal and childhood cancers: An umbrella review of meta-analyses |
title_sort | role of breastfeeding on maternal and childhood cancers: an umbrella review of meta-analyses |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288171/ https://www.ncbi.nlm.nih.gov/pubmed/37350093 http://dx.doi.org/10.7189/jogh.13.04067 |
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