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Zafirlukast Is a Promising Scaffold for Selectively Inhibiting TNFR1 Signaling

[Image: see text] Tumor necrosis factor (TNF) plays an important role in the pathogenesis of inflammatory and autoimmune diseases such as rheumatoid arthritis and Crohn’s disease. The biological effects of TNF are mediated by binding to TNF receptors, TNF receptor 1 (TNFR1), or TNF receptor 2 (TNFR2...

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Detalles Bibliográficos
Autores principales:	Vunnam, Nagamani, Yang, Mu, Lo, Chih Hung, Paulson, Carolyn, Fiers, William D., Huber, Evan, Been, MaryJane, Ferguson, David M., Sachs, Jonathan N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288500/ https://www.ncbi.nlm.nih.gov/pubmed/37363080 http://dx.doi.org/10.1021/acsbiomedchemau.2c00048

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