MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response

[Image: see text] Mucin expression and glycosylation patterns on cancer cells differ markedly from healthy cells. Mucin 1 (MUC1) is overexpressed in several solid tumors and presents high levels of aberrant, truncated O-glycans (e.g., Tn antigen). Dendritic cells (DCs) express lectins that bind to t...

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Detalles Bibliográficos
Autores principales: Gabba, Adele, Attariya, Riem, Behren, Sandra, Pett, Christian, van der Horst, Joost C., Yurugi, Hajime, Yu, Jin, Urschbach, Moritz, Sabin, Juan, Birrane, Gabriel, Schmitt, Edgar, van Vliet, Sandra J., Besenius, Pol, Westerlind, Ulrika, Murphy, Paul V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288512/
https://www.ncbi.nlm.nih.gov/pubmed/37279388
http://dx.doi.org/10.1021/jacs.2c12843

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