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MBD2a–NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression

During human development, there is a switch in the erythroid compartment at birth that results in silencing of expression of fetal hemoglobin (HbF). Reversal of this silencing has been shown to be effective in overcoming the pathophysiologic defect in sickle cell anemia. Among the many transcription...

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Detalles Bibliográficos
Autores principales: Shang, Shengzhe, Li, Xia, Azzo, Alexander, Truong, Tin, Dozmorov, Mikhail, Lyons, Charles, Manna, Asit K., Williams, David C., Ginder, Gordon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288633/
https://www.ncbi.nlm.nih.gov/pubmed/37307480
http://dx.doi.org/10.1073/pnas.2302254120