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Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population
BACKGROUND: The evidence on the association between the triglyceride glucose (TyG) index and the risk of death in the general population remains controversial. This study aims to investigate the relationship between the TyG index and all-cause and cardiovascular mortality in the general population,...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288670/ https://www.ncbi.nlm.nih.gov/pubmed/37349808 http://dx.doi.org/10.1186/s13098-023-01117-7 |
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author | Yu, Yu Wang, Jing Ding, Ligang Huang, Hao Cheng, Sijing Deng, Yu Gu, Min Cai, Chi Ning, Xiaohui Chen, Xuhua Niu, Hongxia Hua, Wei |
author_facet | Yu, Yu Wang, Jing Ding, Ligang Huang, Hao Cheng, Sijing Deng, Yu Gu, Min Cai, Chi Ning, Xiaohui Chen, Xuhua Niu, Hongxia Hua, Wei |
author_sort | Yu, Yu |
collection | PubMed |
description | BACKGROUND: The evidence on the association between the triglyceride glucose (TyG) index and the risk of death in the general population remains controversial. This study aims to investigate the relationship between the TyG index and all-cause and cardiovascular mortality in the general population, with a focus on sex differences. METHODS: This prospective cohort study analyzed data from the National Health and Nutrition Examination Survey (1999–2002), comprising 7,851 US adults. The study employed multivariate Cox proportional hazards regression and two-segment Cox hazard regression models to evaluate the sex-specific differences in the relationship between the TyG index and all-cause and cardiovascular mortality. RESULTS: After 11,623 person-years of follow-up, there were 539 deaths, with 10.56% due to all-cause mortality and 2.87% due to cardiovascular mortality. After adjusting for multiple variables, our study found a U-shaped association of the TyG index with all-cause and cardiovascular mortality, with inflection points at 9.36 and 9.52. A significant sex difference was observed in the association between the TyG index and mortality. Below the inflection point, the relationship between the TyG index and mortality was consistent in males and females. However, above the inflection point, only males exhibited a positive association between the TyG index and all-cause mortality (adjusted hazard risk [HR], 1.62, 95% confidence interval [CI], 1.24–2.12) and cardiovascular mortality (adjusted HR, 2.28, 95% CI, 1.32–3.92). CONCLUSIONS: Our study showed a U-shaped association between the TyG index and all-cause and cardiovascular mortality in the general population. Furthermore, sex differences were observed in the association between the TyG index and mortality once it exceeded a certain threshold. |
format | Online Article Text |
id | pubmed-10288670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102886702023-06-24 Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population Yu, Yu Wang, Jing Ding, Ligang Huang, Hao Cheng, Sijing Deng, Yu Gu, Min Cai, Chi Ning, Xiaohui Chen, Xuhua Niu, Hongxia Hua, Wei Diabetol Metab Syndr Research BACKGROUND: The evidence on the association between the triglyceride glucose (TyG) index and the risk of death in the general population remains controversial. This study aims to investigate the relationship between the TyG index and all-cause and cardiovascular mortality in the general population, with a focus on sex differences. METHODS: This prospective cohort study analyzed data from the National Health and Nutrition Examination Survey (1999–2002), comprising 7,851 US adults. The study employed multivariate Cox proportional hazards regression and two-segment Cox hazard regression models to evaluate the sex-specific differences in the relationship between the TyG index and all-cause and cardiovascular mortality. RESULTS: After 11,623 person-years of follow-up, there were 539 deaths, with 10.56% due to all-cause mortality and 2.87% due to cardiovascular mortality. After adjusting for multiple variables, our study found a U-shaped association of the TyG index with all-cause and cardiovascular mortality, with inflection points at 9.36 and 9.52. A significant sex difference was observed in the association between the TyG index and mortality. Below the inflection point, the relationship between the TyG index and mortality was consistent in males and females. However, above the inflection point, only males exhibited a positive association between the TyG index and all-cause mortality (adjusted hazard risk [HR], 1.62, 95% confidence interval [CI], 1.24–2.12) and cardiovascular mortality (adjusted HR, 2.28, 95% CI, 1.32–3.92). CONCLUSIONS: Our study showed a U-shaped association between the TyG index and all-cause and cardiovascular mortality in the general population. Furthermore, sex differences were observed in the association between the TyG index and mortality once it exceeded a certain threshold. BioMed Central 2023-06-23 /pmc/articles/PMC10288670/ /pubmed/37349808 http://dx.doi.org/10.1186/s13098-023-01117-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yu, Yu Wang, Jing Ding, Ligang Huang, Hao Cheng, Sijing Deng, Yu Gu, Min Cai, Chi Ning, Xiaohui Chen, Xuhua Niu, Hongxia Hua, Wei Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population |
title | Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population |
title_full | Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population |
title_fullStr | Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population |
title_full_unstemmed | Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population |
title_short | Sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population |
title_sort | sex differences in the nonlinear association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288670/ https://www.ncbi.nlm.nih.gov/pubmed/37349808 http://dx.doi.org/10.1186/s13098-023-01117-7 |
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