Functional defects in hiPSCs-derived cardiomyocytes from patients with a PLEKHM2-mutation associated with dilated cardiomyopathy and left ventricular non-compaction

Dilated cardiomyopathy (DCM) is a primary myocardial disease, leading to heart failure and excessive risk of sudden cardiac death with rather poorly understood pathophysiology. In 2015, Parvari's group identified a recessive mutation in the autophagy regulator, PLEKHM2 gene, in a family with se...

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Detalles Bibliográficos
Autores principales: Korover, Nataly, Etzion, Sharon, Cherniak, Alexander, Rabinski, Tatiana, Levitas, Aviva, Etzion, Yoram, Ofir, Rivka, Parvari, Ruti, Cohen, Smadar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288792/
https://www.ncbi.nlm.nih.gov/pubmed/37349842
http://dx.doi.org/10.1186/s40659-023-00442-5

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