Genetic deletion of hepatic NCOR1 protects from atherosclerosis by promoting alternative bile acid-metabolism and sterol excretion

BACKGROUND: The nuclear receptor corepressor 1 (NCOR1) plays an important role in the regulation of gene expression in immunometabolic conditions by connecting chromatin-modifying enzymes, coregulators and transcription factors. NCOR1 has been shown to be involved in cardiometabolic diseases. Recent...

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Detalles Bibliográficos
Autores principales: Geiger, Martin, Oppi, Sara, Nusser-Stein, Stefanie, Costantino, Sarah, Mohammed, Shafeeq Ahmed, Gorica, Era, Hoogerland, Joanne A., Matter, Christian M., Guillaumon, Ana T., Ruschitzka, Frank, Paneni, Francesco, Oosterveer, Maaike H., Stein, Sokrates
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288794/
https://www.ncbi.nlm.nih.gov/pubmed/37349757
http://dx.doi.org/10.1186/s12933-023-01865-w

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