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Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression

Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one type of post-translational modifications, has been demonstrated to accelerate or ameliorate the development and...

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Autores principales: Zheng, Chenxiao, Chen, Jiayi, Wu, Yurui, Wang, Xiaochao, Lin, Yongan, Shu, Lilu, Liu, Wenjun, Wang, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288844/
https://www.ncbi.nlm.nih.gov/pubmed/37359559
http://dx.doi.org/10.3389/fimmu.2023.1217466
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author Zheng, Chenxiao
Chen, Jiayi
Wu, Yurui
Wang, Xiaochao
Lin, Yongan
Shu, Lilu
Liu, Wenjun
Wang, Peter
author_facet Zheng, Chenxiao
Chen, Jiayi
Wu, Yurui
Wang, Xiaochao
Lin, Yongan
Shu, Lilu
Liu, Wenjun
Wang, Peter
author_sort Zheng, Chenxiao
collection PubMed
description Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one type of post-translational modifications, has been demonstrated to accelerate or ameliorate the development and progression of osteoarthritis via targeting specific proteins for ubiquitination and determining protein stability and localization. Ubiquitination process can be reversed by a class of deubiquitinases via deubiquitination. In this review, we summarize the current knowledge regarding the multifaceted role of E3 ubiquitin ligases in the pathogenesis of osteoarthritis. We also describe the molecular insight of deubiquitinases into osteoarthritis processes. Moreover, we highlight the multiple compounds that target E3 ubiquitin ligases or deubiquitinases to influence osteoarthritis progression. We discuss the challenge and future perspectives via modulation of E3 ubiquitin ligases and deubiquitinases expression for enhancement of the therapeutic efficacy in osteoarthritis patients. We conclude that modulating ubiquitination and deubiquitination could alleviate the osteoarthritis pathogenesis to achieve the better treatment outcomes in osteoarthritis patients.
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spelling pubmed-102888442023-06-24 Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression Zheng, Chenxiao Chen, Jiayi Wu, Yurui Wang, Xiaochao Lin, Yongan Shu, Lilu Liu, Wenjun Wang, Peter Front Immunol Immunology Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one type of post-translational modifications, has been demonstrated to accelerate or ameliorate the development and progression of osteoarthritis via targeting specific proteins for ubiquitination and determining protein stability and localization. Ubiquitination process can be reversed by a class of deubiquitinases via deubiquitination. In this review, we summarize the current knowledge regarding the multifaceted role of E3 ubiquitin ligases in the pathogenesis of osteoarthritis. We also describe the molecular insight of deubiquitinases into osteoarthritis processes. Moreover, we highlight the multiple compounds that target E3 ubiquitin ligases or deubiquitinases to influence osteoarthritis progression. We discuss the challenge and future perspectives via modulation of E3 ubiquitin ligases and deubiquitinases expression for enhancement of the therapeutic efficacy in osteoarthritis patients. We conclude that modulating ubiquitination and deubiquitination could alleviate the osteoarthritis pathogenesis to achieve the better treatment outcomes in osteoarthritis patients. Frontiers Media S.A. 2023-06-09 /pmc/articles/PMC10288844/ /pubmed/37359559 http://dx.doi.org/10.3389/fimmu.2023.1217466 Text en Copyright © 2023 Zheng, Chen, Wu, Wang, Lin, Shu, Liu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zheng, Chenxiao
Chen, Jiayi
Wu, Yurui
Wang, Xiaochao
Lin, Yongan
Shu, Lilu
Liu, Wenjun
Wang, Peter
Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
title Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
title_full Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
title_fullStr Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
title_full_unstemmed Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
title_short Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
title_sort elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288844/
https://www.ncbi.nlm.nih.gov/pubmed/37359559
http://dx.doi.org/10.3389/fimmu.2023.1217466
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