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A phase Ib trial of combined PKC and MEK inhibition with sotrastaurin and binimetinib in patients with metastatic uveal melanoma

BACKGROUND: Uveal melanoma is a disease characterized by constitutive activation of the G alpha pathway and downstream signaling of protein kinase C (PKC) and the mitogen-activated protein kinase (MAPK) pathway. While limited clinical activity has been observed in patients with metastatic disease wi...

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Detalles Bibliográficos
Autores principales:	Bauer, Sebastian, Larkin, James, Hodi, F. Stephen, Stephen, Frank, Kapiteijn, Ellen H. W., Schwartz, Gary K., Calvo, Emilano, Yerramilli-Rao, Padmaja, Piperno-Neumann, Sophie, Carvajal, Richard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288853/ https://www.ncbi.nlm.nih.gov/pubmed/37359242 http://dx.doi.org/10.3389/fonc.2022.975642

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