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Characterization of 2 Novel Phosphodiesterase 2 Inhibitors Hcyb1 and PF-05180999 on Depression- and Anxiety-Like Behavior

BACKGROUND: Phosphodiesterase 2A (PDE2A) represents a novel target for new therapies addressing psychiatric disorders. To date, the development of PDE2A inhibitors suitable for human clinical evaluation has been hampered by the poor brain accessibility and metabolic stability of the available compou...

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Detalles Bibliográficos
Autores principales:	Yan, Yuqing, Zhao, Yuhan, Lu, Yue, Acharya, Abhinav P, Wang, Wei, Zhan, Chang-Guo, Ye, Jianghong, Du, Fu, Zhu, Xiongwei, Xu, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Regular Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289143/ https://www.ncbi.nlm.nih.gov/pubmed/37208298 http://dx.doi.org/10.1093/ijnp/pyad020

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