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Hexahydroquinoline Derivatives Are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56

GPR56 is a widely expressed adhesion GPCR (AGPCR) that has pleotropic roles in brain development, platelet function, cancer, and more. Nearly all AGPCRs possess extracellular regions that bind protein ligands and conceal a cryptic tethered peptide agonist. AGPCR reception of mechanical or shear forc...

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Detalles Bibliográficos
Autores principales:	Vizurraga, Alexander L., Robertson, Michael J., Yu, Maiya, Skiniotis, Georgios, Tall, Gregory G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289240/ https://www.ncbi.nlm.nih.gov/pubmed/37290962 http://dx.doi.org/10.1124/molpharm.123.000688

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