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A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study

BACKGROUND AND OBJECTIVES: Insulin resistance (IR) is closely related to the decline or deficiency of testosterone in males. Triglyceride glucose-body mass (TyG-BMI) is considered to be a novel indicator of IR. We conducted this analysis to investigate the association between TyG-BMI and male testos...

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Autores principales: Wu, Shenghao, Wu, Yanhong, Fang, Lizi, Zhao, Junzhao, Cai, Yaoyao, Xia, Weiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289259/
https://www.ncbi.nlm.nih.gov/pubmed/37361537
http://dx.doi.org/10.3389/fendo.2023.1187212
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author Wu, Shenghao
Wu, Yanhong
Fang, Lizi
Zhao, Junzhao
Cai, Yaoyao
Xia, Weiting
author_facet Wu, Shenghao
Wu, Yanhong
Fang, Lizi
Zhao, Junzhao
Cai, Yaoyao
Xia, Weiting
author_sort Wu, Shenghao
collection PubMed
description BACKGROUND AND OBJECTIVES: Insulin resistance (IR) is closely related to the decline or deficiency of testosterone in males. Triglyceride glucose-body mass (TyG-BMI) is considered to be a novel indicator of IR. We conducted this analysis to investigate the association between TyG-BMI and male testosterone, and to explore whether its ability to predict testosterone deficiency is superior to HOMA-IR and TyG. METHODS: This was a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES, 2011–2016). The TyG-BMI index was calculated from serum triglyceride, fasting plasma glucose and BMI. The association of TyG-BMI with male testosterone was estimated by weighted multivariable regression. RESULTS: We included 3394 participants for the final analysis. After adjusting for confounders, TyG-BMI was found to show an independent negative association with testosterone (β=-1.12, 95%CI: -1.50, -0.75, P<0.0001). Multivariate-adjusted beta also showed testosterone levels were significantly lower in the two highest TyG-BMI group (Q3, Q4) compared to the lowest group (Q1). Similar results were seen in all of the subgroup populations by stratified analysis (all P-interaction >0.05). Furthermore, ROC curve analysis indicated that the area under the curve of TyG-BMI index (0.73, 95% CI: 0.71, 0.75) was larger than that of HOMA-IR index (0.71, 95% CI: 0.69, 0.73) and TyG index (0.66, 95% CI: 0.64, 0.68). CONCLUSION: Our result suggested a negative association between TyG-BMI index and testosterone in adult males. The predictability of the TyG-BMI index for testosterone deficiency is better than that of HOMA-IR index and TyG index.
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spelling pubmed-102892592023-06-24 A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study Wu, Shenghao Wu, Yanhong Fang, Lizi Zhao, Junzhao Cai, Yaoyao Xia, Weiting Front Endocrinol (Lausanne) Endocrinology BACKGROUND AND OBJECTIVES: Insulin resistance (IR) is closely related to the decline or deficiency of testosterone in males. Triglyceride glucose-body mass (TyG-BMI) is considered to be a novel indicator of IR. We conducted this analysis to investigate the association between TyG-BMI and male testosterone, and to explore whether its ability to predict testosterone deficiency is superior to HOMA-IR and TyG. METHODS: This was a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES, 2011–2016). The TyG-BMI index was calculated from serum triglyceride, fasting plasma glucose and BMI. The association of TyG-BMI with male testosterone was estimated by weighted multivariable regression. RESULTS: We included 3394 participants for the final analysis. After adjusting for confounders, TyG-BMI was found to show an independent negative association with testosterone (β=-1.12, 95%CI: -1.50, -0.75, P<0.0001). Multivariate-adjusted beta also showed testosterone levels were significantly lower in the two highest TyG-BMI group (Q3, Q4) compared to the lowest group (Q1). Similar results were seen in all of the subgroup populations by stratified analysis (all P-interaction >0.05). Furthermore, ROC curve analysis indicated that the area under the curve of TyG-BMI index (0.73, 95% CI: 0.71, 0.75) was larger than that of HOMA-IR index (0.71, 95% CI: 0.69, 0.73) and TyG index (0.66, 95% CI: 0.64, 0.68). CONCLUSION: Our result suggested a negative association between TyG-BMI index and testosterone in adult males. The predictability of the TyG-BMI index for testosterone deficiency is better than that of HOMA-IR index and TyG index. Frontiers Media S.A. 2023-06-09 /pmc/articles/PMC10289259/ /pubmed/37361537 http://dx.doi.org/10.3389/fendo.2023.1187212 Text en Copyright © 2023 Wu, Wu, Fang, Zhao, Cai and Xia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wu, Shenghao
Wu, Yanhong
Fang, Lizi
Zhao, Junzhao
Cai, Yaoyao
Xia, Weiting
A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
title A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
title_full A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
title_fullStr A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
title_full_unstemmed A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
title_short A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
title_sort negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289259/
https://www.ncbi.nlm.nih.gov/pubmed/37361537
http://dx.doi.org/10.3389/fendo.2023.1187212
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