The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems

Type III CRISPR-Cas systems employ multiprotein effector complexes bound to small CRISPR RNAs (crRNAs) to detect foreign RNA transcripts and elicit a complex immune response that leads to the destruction of invading RNA and DNA. Type III systems are among the most widespread in nature, and emerging...

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Detalles Bibliográficos
Autores principales: Paraan, Mohammadreza, Nasef, Mohamed, Chou-Zheng, Lucy, Khweis, Sarah A., Schoeffler, Allyn J., Hatoum-Aslan, Asma, Stagg, Scott M., Dunkle, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289348/
https://www.ncbi.nlm.nih.gov/pubmed/37352230
http://dx.doi.org/10.1371/journal.pone.0287461

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