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The analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study

Early-onset colorectal cancer (CRC) has different clinical and pathological characteristics compared with late-onset CRC. Mortality rate as a postoperative outcome is a patient’s postoperative outcome considered based on the state of life or death. The objective of this research is to analyse the co...

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Autores principales: Lukman, Kiki, Mulyawan, Andi, Nugrahani, Annisa Dewi, Rudiman, Reno, Primastari, Etis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289482/
https://www.ncbi.nlm.nih.gov/pubmed/37363503
http://dx.doi.org/10.1097/MS9.0000000000000757
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author Lukman, Kiki
Mulyawan, Andi
Nugrahani, Annisa Dewi
Rudiman, Reno
Primastari, Etis
author_facet Lukman, Kiki
Mulyawan, Andi
Nugrahani, Annisa Dewi
Rudiman, Reno
Primastari, Etis
author_sort Lukman, Kiki
collection PubMed
description Early-onset colorectal cancer (CRC) has different clinical and pathological characteristics compared with late-onset CRC. Mortality rate as a postoperative outcome is a patient’s postoperative outcome considered based on the state of life or death. The objective of this research is to analyse the comparison between clinicopathological aspect of early-onset vs. late-onset CRC as well as their correlation with the mortality rate in Indonesia to support global data. MATERIAL AND METHODS: The authors performed a case-control study on 170 subjects with CRC from November 2021 to November 2022 in a Tertiary Hospital in Bandung. Data were extracted from electronic medical records CRC Registry. Bivariate and correlation analyses were used to analyse the difference between variables using IBM SPSS 24.0. P less than 0.05 was considered statistically significant. RESULTS: Anaemia and tumour location variables were significantly different in the early-onset group compared with the late-onset group (P<0.001). It was also found that anaemia (P<0.001), pathological features (P<0.001), and tumour location (P=0.013) had significantly low correlation with onset of CRC (r=0.325; r=0.397; r=0.342, respectively). CONCLUSION: There is no statistically significant correlation between the clinicopathological features of CRC in both onset and mortality rates in this study.
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spelling pubmed-102894822023-06-24 The analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study Lukman, Kiki Mulyawan, Andi Nugrahani, Annisa Dewi Rudiman, Reno Primastari, Etis Ann Med Surg (Lond) Original Research Early-onset colorectal cancer (CRC) has different clinical and pathological characteristics compared with late-onset CRC. Mortality rate as a postoperative outcome is a patient’s postoperative outcome considered based on the state of life or death. The objective of this research is to analyse the comparison between clinicopathological aspect of early-onset vs. late-onset CRC as well as their correlation with the mortality rate in Indonesia to support global data. MATERIAL AND METHODS: The authors performed a case-control study on 170 subjects with CRC from November 2021 to November 2022 in a Tertiary Hospital in Bandung. Data were extracted from electronic medical records CRC Registry. Bivariate and correlation analyses were used to analyse the difference between variables using IBM SPSS 24.0. P less than 0.05 was considered statistically significant. RESULTS: Anaemia and tumour location variables were significantly different in the early-onset group compared with the late-onset group (P<0.001). It was also found that anaemia (P<0.001), pathological features (P<0.001), and tumour location (P=0.013) had significantly low correlation with onset of CRC (r=0.325; r=0.397; r=0.342, respectively). CONCLUSION: There is no statistically significant correlation between the clinicopathological features of CRC in both onset and mortality rates in this study. Lippincott Williams & Wilkins 2023-05-03 /pmc/articles/PMC10289482/ /pubmed/37363503 http://dx.doi.org/10.1097/MS9.0000000000000757 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0 (https://creativecommons.org/licenses/by-nd/4.0/) , which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/)
spellingShingle Original Research
Lukman, Kiki
Mulyawan, Andi
Nugrahani, Annisa Dewi
Rudiman, Reno
Primastari, Etis
The analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study
title The analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study
title_full The analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study
title_fullStr The analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study
title_full_unstemmed The analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study
title_short The analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study
title_sort analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289482/
https://www.ncbi.nlm.nih.gov/pubmed/37363503
http://dx.doi.org/10.1097/MS9.0000000000000757
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