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Hepatitis-E-induced cholestasis in a child: a case report

Hepatitis E virus (HEV) is a major cause of epidemic water-borne hepatitis in tropical and subtropical countries in areas with poor sanitary conditions. The infection by HEV in children is frequent but typically asymptomatic or manifested only as a very mild disease without jaundice, and usually, it...

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Autores principales: Pokhrel, Sagar, Bhusal, Amrit, Kumari, Neelam, Bhattarai, Himal Bikram, Banjade, Aneeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289493/
https://www.ncbi.nlm.nih.gov/pubmed/37363502
http://dx.doi.org/10.1097/MS9.0000000000000748
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author Pokhrel, Sagar
Bhusal, Amrit
Kumari, Neelam
Bhattarai, Himal Bikram
Banjade, Aneeta
author_facet Pokhrel, Sagar
Bhusal, Amrit
Kumari, Neelam
Bhattarai, Himal Bikram
Banjade, Aneeta
author_sort Pokhrel, Sagar
collection PubMed
description Hepatitis E virus (HEV) is a major cause of epidemic water-borne hepatitis in tropical and subtropical countries in areas with poor sanitary conditions. The infection by HEV in children is frequent but typically asymptomatic or manifested only as a very mild disease without jaundice, and usually, it often goes undiagnosed. In this case report, the authors describe a case of hepatitis-E-induced cholestasis in a child. CASE PRESENTATION: An 8-year-old male child presented to a Pediatrics emergency with fever and features of acute cholestasis. On abdominal examination, there was non-tender hepatomegaly. The rest of the systemic examinations were normal. Ultrasonography findings were suggestive of acute hepatitis. The liver biopsy report showed hepatic cholestasis and hepatitis. The serological test for hepatitis E IgM was positive. The child was managed symptomatically. CONCLUSION: Although cholestasis is uncommon in children with HEV infection, it should be considered for non-improving clinical status in children with hepatitis. Also, patients with jaundice and Hepatitis E should be followed up by treating physicians until resolution occurs. To the authors’ knowledge, this is the first case report from Nepal describing cholestasis in a child due to HEV infection.
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spelling pubmed-102894932023-06-24 Hepatitis-E-induced cholestasis in a child: a case report Pokhrel, Sagar Bhusal, Amrit Kumari, Neelam Bhattarai, Himal Bikram Banjade, Aneeta Ann Med Surg (Lond) Case Reports Hepatitis E virus (HEV) is a major cause of epidemic water-borne hepatitis in tropical and subtropical countries in areas with poor sanitary conditions. The infection by HEV in children is frequent but typically asymptomatic or manifested only as a very mild disease without jaundice, and usually, it often goes undiagnosed. In this case report, the authors describe a case of hepatitis-E-induced cholestasis in a child. CASE PRESENTATION: An 8-year-old male child presented to a Pediatrics emergency with fever and features of acute cholestasis. On abdominal examination, there was non-tender hepatomegaly. The rest of the systemic examinations were normal. Ultrasonography findings were suggestive of acute hepatitis. The liver biopsy report showed hepatic cholestasis and hepatitis. The serological test for hepatitis E IgM was positive. The child was managed symptomatically. CONCLUSION: Although cholestasis is uncommon in children with HEV infection, it should be considered for non-improving clinical status in children with hepatitis. Also, patients with jaundice and Hepatitis E should be followed up by treating physicians until resolution occurs. To the authors’ knowledge, this is the first case report from Nepal describing cholestasis in a child due to HEV infection. Lippincott Williams & Wilkins 2023-04-27 /pmc/articles/PMC10289493/ /pubmed/37363502 http://dx.doi.org/10.1097/MS9.0000000000000748 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (https://creativecommons.org/licenses/by-nc/4.0/) (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Case Reports
Pokhrel, Sagar
Bhusal, Amrit
Kumari, Neelam
Bhattarai, Himal Bikram
Banjade, Aneeta
Hepatitis-E-induced cholestasis in a child: a case report
title Hepatitis-E-induced cholestasis in a child: a case report
title_full Hepatitis-E-induced cholestasis in a child: a case report
title_fullStr Hepatitis-E-induced cholestasis in a child: a case report
title_full_unstemmed Hepatitis-E-induced cholestasis in a child: a case report
title_short Hepatitis-E-induced cholestasis in a child: a case report
title_sort hepatitis-e-induced cholestasis in a child: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289493/
https://www.ncbi.nlm.nih.gov/pubmed/37363502
http://dx.doi.org/10.1097/MS9.0000000000000748
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