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Hepatitis-E-induced cholestasis in a child: a case report
Hepatitis E virus (HEV) is a major cause of epidemic water-borne hepatitis in tropical and subtropical countries in areas with poor sanitary conditions. The infection by HEV in children is frequent but typically asymptomatic or manifested only as a very mild disease without jaundice, and usually, it...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289493/ https://www.ncbi.nlm.nih.gov/pubmed/37363502 http://dx.doi.org/10.1097/MS9.0000000000000748 |
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author | Pokhrel, Sagar Bhusal, Amrit Kumari, Neelam Bhattarai, Himal Bikram Banjade, Aneeta |
author_facet | Pokhrel, Sagar Bhusal, Amrit Kumari, Neelam Bhattarai, Himal Bikram Banjade, Aneeta |
author_sort | Pokhrel, Sagar |
collection | PubMed |
description | Hepatitis E virus (HEV) is a major cause of epidemic water-borne hepatitis in tropical and subtropical countries in areas with poor sanitary conditions. The infection by HEV in children is frequent but typically asymptomatic or manifested only as a very mild disease without jaundice, and usually, it often goes undiagnosed. In this case report, the authors describe a case of hepatitis-E-induced cholestasis in a child. CASE PRESENTATION: An 8-year-old male child presented to a Pediatrics emergency with fever and features of acute cholestasis. On abdominal examination, there was non-tender hepatomegaly. The rest of the systemic examinations were normal. Ultrasonography findings were suggestive of acute hepatitis. The liver biopsy report showed hepatic cholestasis and hepatitis. The serological test for hepatitis E IgM was positive. The child was managed symptomatically. CONCLUSION: Although cholestasis is uncommon in children with HEV infection, it should be considered for non-improving clinical status in children with hepatitis. Also, patients with jaundice and Hepatitis E should be followed up by treating physicians until resolution occurs. To the authors’ knowledge, this is the first case report from Nepal describing cholestasis in a child due to HEV infection. |
format | Online Article Text |
id | pubmed-10289493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-102894932023-06-24 Hepatitis-E-induced cholestasis in a child: a case report Pokhrel, Sagar Bhusal, Amrit Kumari, Neelam Bhattarai, Himal Bikram Banjade, Aneeta Ann Med Surg (Lond) Case Reports Hepatitis E virus (HEV) is a major cause of epidemic water-borne hepatitis in tropical and subtropical countries in areas with poor sanitary conditions. The infection by HEV in children is frequent but typically asymptomatic or manifested only as a very mild disease without jaundice, and usually, it often goes undiagnosed. In this case report, the authors describe a case of hepatitis-E-induced cholestasis in a child. CASE PRESENTATION: An 8-year-old male child presented to a Pediatrics emergency with fever and features of acute cholestasis. On abdominal examination, there was non-tender hepatomegaly. The rest of the systemic examinations were normal. Ultrasonography findings were suggestive of acute hepatitis. The liver biopsy report showed hepatic cholestasis and hepatitis. The serological test for hepatitis E IgM was positive. The child was managed symptomatically. CONCLUSION: Although cholestasis is uncommon in children with HEV infection, it should be considered for non-improving clinical status in children with hepatitis. Also, patients with jaundice and Hepatitis E should be followed up by treating physicians until resolution occurs. To the authors’ knowledge, this is the first case report from Nepal describing cholestasis in a child due to HEV infection. Lippincott Williams & Wilkins 2023-04-27 /pmc/articles/PMC10289493/ /pubmed/37363502 http://dx.doi.org/10.1097/MS9.0000000000000748 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (https://creativecommons.org/licenses/by-nc/4.0/) (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Case Reports Pokhrel, Sagar Bhusal, Amrit Kumari, Neelam Bhattarai, Himal Bikram Banjade, Aneeta Hepatitis-E-induced cholestasis in a child: a case report |
title | Hepatitis-E-induced cholestasis in a child: a case report |
title_full | Hepatitis-E-induced cholestasis in a child: a case report |
title_fullStr | Hepatitis-E-induced cholestasis in a child: a case report |
title_full_unstemmed | Hepatitis-E-induced cholestasis in a child: a case report |
title_short | Hepatitis-E-induced cholestasis in a child: a case report |
title_sort | hepatitis-e-induced cholestasis in a child: a case report |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289493/ https://www.ncbi.nlm.nih.gov/pubmed/37363502 http://dx.doi.org/10.1097/MS9.0000000000000748 |
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