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The pattern of sarcoid uveitis at a tertiary care center in Nepal

Sarcoidosis is an idiopathic, multisystemic granulomatous disorder involving the eye with various ocular presentations, the most common being sarcoid uveitis. The diagnosis was based on typical clinical features, chest radiography, laboratory findings and biopsy based on revised International Worksh...

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Autores principales: Kharel (Sitaula), Ranju, Poudel, Arika, Shrestha, Shreeji, Jha, Saket
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289532/
https://www.ncbi.nlm.nih.gov/pubmed/37363455
http://dx.doi.org/10.1097/MS9.0000000000000853
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author Kharel (Sitaula), Ranju
Poudel, Arika
Shrestha, Shreeji
Jha, Saket
author_facet Kharel (Sitaula), Ranju
Poudel, Arika
Shrestha, Shreeji
Jha, Saket
author_sort Kharel (Sitaula), Ranju
collection PubMed
description Sarcoidosis is an idiopathic, multisystemic granulomatous disorder involving the eye with various ocular presentations, the most common being sarcoid uveitis. The diagnosis was based on typical clinical features, chest radiography, laboratory findings and biopsy based on revised International Workshop on Ocular Sarcoidosis criteria. Here in, the authors aim to present the first report on the trend of cases of sarcoid uveitis in Nepal. MATERIALS AND METHODS: A retrospective quantitative cross-sectional study was conducted at the uveitis clinic of the Institute of Medicine by obtaining medical data from the medical record section on sarcoid uveitis cases visiting from March 2018 to March 2021. Demographic profile, ocular findings, laboratory findings and treatment details were documented and statistical analysis was done via Statistical Program for Social Science (SPSS) version 23. RESULTS: Out of 50 eyes of 30 patients included in the study; 66.6% patients (n=20) had bilateral and 33.3% (n=10) had unilateral ocular involvement. Anterior with intermediate uveitis (26.7%) was the most common type of uveitis among the cases. Serum angiotensin converting enzyme was raised in 66.7%, Chest X-ray showed hilar changes in 63.33%, and high-resolution computed tomography showed mediastinal, hilar lymphadenopathy with or without the involvement of the lung in 63.33% of patients. CONCLUSION: Sarcoid uveitis may have varied ocular presentations, the commonest being anterior and intermediate uveitis. The commonest complications are cataract and cystoid macular oedema, which are associated with vision loss. Steroids and immunomodulators are the mainstays of treatment.
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spelling pubmed-102895322023-06-24 The pattern of sarcoid uveitis at a tertiary care center in Nepal Kharel (Sitaula), Ranju Poudel, Arika Shrestha, Shreeji Jha, Saket Ann Med Surg (Lond) Original Research Sarcoidosis is an idiopathic, multisystemic granulomatous disorder involving the eye with various ocular presentations, the most common being sarcoid uveitis. The diagnosis was based on typical clinical features, chest radiography, laboratory findings and biopsy based on revised International Workshop on Ocular Sarcoidosis criteria. Here in, the authors aim to present the first report on the trend of cases of sarcoid uveitis in Nepal. MATERIALS AND METHODS: A retrospective quantitative cross-sectional study was conducted at the uveitis clinic of the Institute of Medicine by obtaining medical data from the medical record section on sarcoid uveitis cases visiting from March 2018 to March 2021. Demographic profile, ocular findings, laboratory findings and treatment details were documented and statistical analysis was done via Statistical Program for Social Science (SPSS) version 23. RESULTS: Out of 50 eyes of 30 patients included in the study; 66.6% patients (n=20) had bilateral and 33.3% (n=10) had unilateral ocular involvement. Anterior with intermediate uveitis (26.7%) was the most common type of uveitis among the cases. Serum angiotensin converting enzyme was raised in 66.7%, Chest X-ray showed hilar changes in 63.33%, and high-resolution computed tomography showed mediastinal, hilar lymphadenopathy with or without the involvement of the lung in 63.33% of patients. CONCLUSION: Sarcoid uveitis may have varied ocular presentations, the commonest being anterior and intermediate uveitis. The commonest complications are cataract and cystoid macular oedema, which are associated with vision loss. Steroids and immunomodulators are the mainstays of treatment. Lippincott Williams & Wilkins 2023-05-18 /pmc/articles/PMC10289532/ /pubmed/37363455 http://dx.doi.org/10.1097/MS9.0000000000000853 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Research
Kharel (Sitaula), Ranju
Poudel, Arika
Shrestha, Shreeji
Jha, Saket
The pattern of sarcoid uveitis at a tertiary care center in Nepal
title The pattern of sarcoid uveitis at a tertiary care center in Nepal
title_full The pattern of sarcoid uveitis at a tertiary care center in Nepal
title_fullStr The pattern of sarcoid uveitis at a tertiary care center in Nepal
title_full_unstemmed The pattern of sarcoid uveitis at a tertiary care center in Nepal
title_short The pattern of sarcoid uveitis at a tertiary care center in Nepal
title_sort pattern of sarcoid uveitis at a tertiary care center in nepal
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289532/
https://www.ncbi.nlm.nih.gov/pubmed/37363455
http://dx.doi.org/10.1097/MS9.0000000000000853
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