An independent regulator of global release pathways in astrocytes generates a subtype of extracellular vesicles required for postsynaptic function

Extracellular vesicles (EVs) are heterogeneous in size, composition, and function. We show that the six-transmembrane protein glycerophosphodiester phosphodiesterase 3 (GDE3) regulates actin remodeling, a global EV biogenic pathway, to release an EV subtype with distinct functions. GDE3 is necessary...

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Detalles Bibliográficos
Autores principales: Levy-Myers, Reuben, Daudelin, Daniel, Na, Chan Hyun, Sockanathan, Shanthini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289663/
https://www.ncbi.nlm.nih.gov/pubmed/37352348
http://dx.doi.org/10.1126/sciadv.adg2067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289663/
https://www.ncbi.nlm.nih.gov/pubmed/37352348
http://dx.doi.org/10.1126/sciadv.adg2067

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