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Ventilator associated pneumonia in intensive care unit patients: a systematic review

Ventilator-associated pneumonia (VAP) is the most common ICU acquired pneumonia among patients who are invasively intubated for mechanical ventilation. Patients with VAP suffer an increased mortality risk, financial burden, and length of stay in the hospital. The authors aimed to review the literatu...

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Autores principales: Mumtaz, Hassan, Saqib, Muhammad, Khan, Wajiha, Ismail, Syed M., Sohail, Hassan, Muneeb, Muhammad, Sheikh, Shazia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289715/
https://www.ncbi.nlm.nih.gov/pubmed/37363470
http://dx.doi.org/10.1097/MS9.0000000000000836
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author Mumtaz, Hassan
Saqib, Muhammad
Khan, Wajiha
Ismail, Syed M.
Sohail, Hassan
Muneeb, Muhammad
Sheikh, Shazia S.
author_facet Mumtaz, Hassan
Saqib, Muhammad
Khan, Wajiha
Ismail, Syed M.
Sohail, Hassan
Muneeb, Muhammad
Sheikh, Shazia S.
author_sort Mumtaz, Hassan
collection PubMed
description Ventilator-associated pneumonia (VAP) is the most common ICU acquired pneumonia among patients who are invasively intubated for mechanical ventilation. Patients with VAP suffer an increased mortality risk, financial burden, and length of stay in the hospital. The authors aimed to review the literature to describe the incidence, mortality, and microbiological evidence of VAP. We selected 13 peer-reviewed articles published from 1 January 2010 to 15 September 2022 from electronic databases for studies among adult or pediatric patients diagnosed with VAP expressed per thousand days admitted in the ICU. The VAP rates ranged from 7 to 43 per thousand days, varying among different countries of the world. A significant rate of mortality was observed in 13 studies ranging from 6.3 to 66.9%. Gram-negative organisms like Acinetobacter spp., Pseudomonas aeruginosa Gram-positive organisms like Staphylococcus aureus were frequently found. Our findings suggest an alarming situation of VAP among patients admitted to the intensive care units with increasing incidence and mortality. The review also found that VAP is more common in males and that there is a significant variation in the incidence and mortality rates of VAP among different countries. The findings of this review can inform the development of infection control and prevention strategies to reduce the burden of VAP. Thus, there is a crucial need for control and preventive measures like interventional studies and educational programs on staff training, hand-hygiene, and the appropriate use of ventilator bundle approach to curb this preventable threat that is increasing at an alarming rate.
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spelling pubmed-102897152023-06-24 Ventilator associated pneumonia in intensive care unit patients: a systematic review Mumtaz, Hassan Saqib, Muhammad Khan, Wajiha Ismail, Syed M. Sohail, Hassan Muneeb, Muhammad Sheikh, Shazia S. Ann Med Surg (Lond) Review Articles Ventilator-associated pneumonia (VAP) is the most common ICU acquired pneumonia among patients who are invasively intubated for mechanical ventilation. Patients with VAP suffer an increased mortality risk, financial burden, and length of stay in the hospital. The authors aimed to review the literature to describe the incidence, mortality, and microbiological evidence of VAP. We selected 13 peer-reviewed articles published from 1 January 2010 to 15 September 2022 from electronic databases for studies among adult or pediatric patients diagnosed with VAP expressed per thousand days admitted in the ICU. The VAP rates ranged from 7 to 43 per thousand days, varying among different countries of the world. A significant rate of mortality was observed in 13 studies ranging from 6.3 to 66.9%. Gram-negative organisms like Acinetobacter spp., Pseudomonas aeruginosa Gram-positive organisms like Staphylococcus aureus were frequently found. Our findings suggest an alarming situation of VAP among patients admitted to the intensive care units with increasing incidence and mortality. The review also found that VAP is more common in males and that there is a significant variation in the incidence and mortality rates of VAP among different countries. The findings of this review can inform the development of infection control and prevention strategies to reduce the burden of VAP. Thus, there is a crucial need for control and preventive measures like interventional studies and educational programs on staff training, hand-hygiene, and the appropriate use of ventilator bundle approach to curb this preventable threat that is increasing at an alarming rate. Lippincott Williams & Wilkins 2023-05-12 /pmc/articles/PMC10289715/ /pubmed/37363470 http://dx.doi.org/10.1097/MS9.0000000000000836 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (https://creativecommons.org/licenses/by-nc/4.0/) (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Review Articles
Mumtaz, Hassan
Saqib, Muhammad
Khan, Wajiha
Ismail, Syed M.
Sohail, Hassan
Muneeb, Muhammad
Sheikh, Shazia S.
Ventilator associated pneumonia in intensive care unit patients: a systematic review
title Ventilator associated pneumonia in intensive care unit patients: a systematic review
title_full Ventilator associated pneumonia in intensive care unit patients: a systematic review
title_fullStr Ventilator associated pneumonia in intensive care unit patients: a systematic review
title_full_unstemmed Ventilator associated pneumonia in intensive care unit patients: a systematic review
title_short Ventilator associated pneumonia in intensive care unit patients: a systematic review
title_sort ventilator associated pneumonia in intensive care unit patients: a systematic review
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289715/
https://www.ncbi.nlm.nih.gov/pubmed/37363470
http://dx.doi.org/10.1097/MS9.0000000000000836
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